Health Condition 1: G939- Disorder of brain, unspecified Health Condition 2: N178- Other acute kidney failure
Conditions
Interventions
Intervention1: Nil: Nil
Sponsors
Sri Ramachandra Institute of Higher Education and Research.
Eligibility
Inclusion criteria
Inclusion criteria: Diagnosed with chronic kidney disease or acute kidney injury undergoing hemodialysis Clinical suspicion or diagnosis of uremic encephalopathy or neurological symptoms suggestive of raised Intracranial Pressure Patients willing and able to provide informed consent Stable hemodialysis sessions planned during the study period for repeat measurements
Exclusion criteria
Exclusion criteria: Patients with pre-existing neurological disorders unrelated to renal failure (eg traumatic brain injury stroke) to avoid confounding Intracranial Pressure effects History of ocular or optic nerve diseases (optic neuritis glaucoma retinal diseases) or ocular trauma affecting ONSD measurement accuracy Presence of severe visual impairment or inability to undergo ocular ultrasound Patients requiring immediate neurosurgical intervention Those with metabolic encephalopathies other than uremic (eg hepatic septic encephalopathy) Patients with inadequate acoustic window for ocular ultrasound
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Identification of specific dialysis factors (fluid removal volume, ultrafiltration rate blood pressure changes) influencing ONSD(Optic nerve sheath diameter) and ICP. Insight into modifiable dialysis parameters to minimize neurological risks Validation of bedside ocular ultrasound for reliable repeatable ONSD measurement as a feasible ICP surrogate in dialysis unitsTimepoint: 24 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| ONSD values could predict patient prognosis and risk of neurological deterioration potentially guiding dialysis management to improve outcomesTimepoint: 2 years | — |
Countries
India
Contacts
Public ContactDr Renuka M K
Department of Critical Care Medicine
Outcome results
None listed