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A study comparing two sedation methods (dexmedetomidine and midazolam ketamine) to improve comfort during placement of a breathing tube through the nose using a camera in patients undergoing major head and neck cancer surgery

Dexmedetomidine vs midazolam ketamine for sedation during awake fiberoptic nasal intubation in patients undergoing commando operation a randomised, double-blinded, comparative trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/04/107769
Enrollment
58
Registered
2026-04-07
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C060- Malignant neoplasm of cheek mucosa Health Condition 2: C049- Malignant neoplasm of floor of mouth, unspecified Health Condition 3: C039- Malignant neoplasm of gum, unspecified Health Condition 4: C050- Malignant neoplasm of hard palate Health Condition 5: C029- Malignant neoplasm of tongue, unspecified

Interventions

Intervention1: Dexmedetomidine: IV dexmedetomidine 1 mcg/kg diluted in 20 ml NS infused over 10 min and 2mL of Normal Saline in 2ml syringe is administered to produce sedation for doing awake fibre o

Sponsors

Abhijith C R
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients between the age of 18-70 who are willing to participate with ASA grade I-III and is undergoing commando surgery.

Exclusion criteria

Exclusion criteria: Patients unwilling to participate, BMI more than 35, history of Post operative nausea and vomiting, impaired renal function or history of allergy to any of the study drug

Design outcomes

Primary

MeasureTime frame
To compare the sedation level, intubation response and patient comfort achieved by dexmedetomidine vs midazolam -ketamine during awake fibre optic nasal intubation.Timepoint: T0 : baseline T1 : intubation T2 : post intubation—

Secondary

MeasureTime frame
To compare the hemodynamic parameters of the patient during and post intubation after giving each of the study drugsTimepoint: T0 : baseline T1 : intubation T2 : post intubation—

Countries

India

Contacts

Public ContactVishwanath Kumar

RIMS Ranchi

drvishwanathkumar@gmail.com8439512490

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026