FindTrial
Sign In

Study of pupillary responses and heart rate variability to detect autonomic nervous system problems in patients with craniovertebral junction and upper cervical spine disorders

Correlation of Automated Pupillometry with Heart Rate Variability for Autonomic Dysfunction Assessment in Craniovertebral Junction and Upper Cervical Spine Pathologies - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/04/107761
Enrollment
48
Registered
2026-04-07
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G952- Other and unspecified cord compression

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: Nil: Nil Intervention4: Nil: Nil Intervention5: Nil: Nil

Sponsors

Dr Monica S Tandon
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with radiologically confirmed craniovertebral junction (CVJ) or upper cervical spine pathology (e.g., atlantoaxial instability, basilar invagination, Chiari malformation, occipital assimilation, traumatic/degenerative cervical cord compression)

Exclusion criteria

Exclusion criteria: 1) Ocular pathology affecting pupillary reflex (acute anisocoria, severe cataract, acute glaucoma, recent ocular surgery/trauma) 2) Major cardiac arrhythmias or pacemaker rhythm 3) Chronic systemic illnesses significantly altering autonomic function, including, chronic kidney disease, advanced heart disease/heart failure, diabetes with autonomic neuropathy, severe hypothyroidism, Parkinsonism, known primary dysautonomia 4) Medications strongly altering pupils/autonomics within 24 48h: sympathomimetics/adrenergic agonists or antagonists, Beta-blockers, anticholinergics, opioids/sedatives/benzodiazepines, vasoactive agents, mydriatic/miotic eye drops 5) Raised intracranial pressure, poor neurological status, agitation or inability to cooperate 6) Patients with severe disease who might not tolerate transfer to the testing facility 7) ICU admission/ventilation, sepsis, pregnancy

Design outcomes

Primary

MeasureTime frame
Correlation coefficient of Maximum pupillary constriction velocity (Vmax) with HF power (parasympathetic/vagal activity) and Maximum pupillary dilation velocity (Vmax2) and LF/HF ratio (sympatho-vagal balance)Timepoint: Baseline—

Secondary

MeasureTime frame
Correlation coefficients for QPi, latency, T50, baseline pupil diameter vs SDNN, RMSSD, LFTimepoint: Baseline;Diagnostic Agreement (AP vs HRV)Timepoint: Baseline;Diagnostic Accuracy of AP vs HRVTimepoint: Baseline;Correlation with clinical & radiological disease severityTimepoint: Baseline;Feasibility MetricsTimepoint: Baseline;Healthy Reference Cohort OutcomesTimepoint: Baseline—

Countries

India

Contacts

Public ContactDr Monica S Tandon

GB Pant Institute of Postgraduate Medical Education and Research (GIPMER)

monicastandon@hotmail.com9718599408

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026