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A study to see if a drug called calcium gluconate will reduce blood loss in women with moderate anemia undergoing emergency cesarean section

Effect of prophylactic intravenous calcium gluconate on magnitude of postpartum blood loss in women with moderate anemia under- going emergent cesarean section- a double blinded placebo controlled randomized trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/04/107757
Enrollment
134
Registered
2026-04-07
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O721- Other immediate postpartum hemorrhage

Interventions

Intervention1: intravenous calcium gluconate: 1g of calcium gluconate in 90 ml of normal saline in 10 minutes Control Intervention1: normal saline: 100 ml of normal saline in 10 minutes Control Interv

Sponsors

JIPMER
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Pregnant women of age 18-45 years having moderate anemia (Hemoglobin range 7-9.9 as per ICMR classification) at term gestation (37 weeks or beyond) undergoing emergency LSCS under spinal anaesthesia a double blinded placebo controlled randomised study Serum calcium levels will be tested before giving calcium gluconate to avoid hypercalcemia.

Exclusion criteria

Exclusion criteria: Previous caesarean section 1)Patients on MgSO4 2) Fetuses with major congenital anomalies 3)Renal dysfunction with serum Creatinine greater than 1.0 mg/dl 4)Known history of maternal cardiac disease including arrhythmia ischemic and congenital cardiac disease 5) Treatment with digoxin within the last 2 weeks 6) Pre-existing bleeding disorders and established DIC 7)Patient with pulmonary edema

Design outcomes

Primary

MeasureTime frame
postpartum blood loss in mlTimepoint: 1 hour—

Secondary

MeasureTime frame
Maternal hemodynamic status Timepoint: 1 hour;Uterine tone score Timepoint: 1 hour;Need for additional uterotonic agents (methylergometrine/ prostaglandins F2alfa/E1) Timepoint: 1 hour;Need for blood transfusions Timepoint: 24 hours;Need for inotropic support Timepoint: 1 hour;Need for other surgical interventions for management of PPH Timepoint: 1 hour;Difference in mean hemoglobin level pre and postoperatively. Timepoint: 2 hours;Incidence of post partum severe anemia. Hb less than 7gTimepoint: 24 hours—

Countries

India

Contacts

Public ContactShylvia Christy J

JIPMER, Puducherry

shylviachristy31@gmail.com9500895990

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026