Study of oral ivabradine to reduce rise in heart rate and blood pressure during insertion of breathing tube for anesthesia in hypertensive and normotensive patients.

A study to evaluate and compare the efficacy of oral ivabradine for attenuating the hemodynamic responses to laryngoscopy and endotracheal intubation in hypertensive versus normotensive patients - randomise comparative study at SMS Medical College Jaipur - Nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/04/107719

Enrollment

Registered

2026-04-07

Start date

Unknown

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I10- Essential (primary) hypertension Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Preoperative single dose of oral ivabradine 5mg in hypertensive pateints: To compare the efficacy of oral ivabradine in attenutaing hemodynamic response to endotracheal intubation in n

Eligibility

Inclusion criteria

Inclusion criteria: Normotensive and controlled hypertensive patients on medication consenting to participate , belonging to American Society of Anesthesiologist (ASA) I -II aged 30-60 years undergoing elective surgery.

Exclusion criteria

Exclusion criteria: 1.Pateint not consenting to participate. 2.Difficult airway ,obesity (BMI more than 30). 3.Baseline heart rate less than 60 or more than 100. 4.Cardiorespiratory diseases. 5.Pregnancy. 6.Drug interacting with ivabradine. 7.Patient on beta blocker therapy. 8.Hypersensitivity to ivabradine.

Design outcomes

Primary

Measure	Time frame
heart rate , systolic blood pressure, diastolic blood pressure, mean blood pressureTimepoint: At intubation and post intubation at 1,2,3,4,5 and 10 minutes.	—

Secondary

Measure	Time frame
Rate pressure product & perfusion indexTimepoint: At intubation & post intubation at 1,2,3,4,5 & 10 minutes	—

Countries

India

Contacts

Public ContactDr Rakesh A

SMS Medical College and attached Hospitals,Jaipur

sunitameena98@gmail.com9461290011

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026