Health Condition 1: O149- Unspecified pre-eclampsia
Conditions
Interventions
Intervention1: Nil: Nil
Intervention2: Nil: Nil
Intervention3: Nil: Nil
Intervention4: Nil: Nil
Control Intervention1: Nil: Nil
Sponsors
Concept Foundation
Eligibility
Inclusion criteria
Inclusion criteria: 1. Pregnant women with a viable pregnancy, from 11 weeks and 0 days to less than 20 weeks gestation 2. Single or multiple gestation 3. Willing, able and consent to a follow-up cohort study 4. Intend to deliver at a participating facility 5. Pregnant women less than 18 years of age
Exclusion criteria
Exclusion criteria: 1. Pregnant women less than 11 weeks and 0 days and more than 20 weeks gestation 2. Not willing or not able and consent to a follow-up cohort study 3. Pregnant women less than 18 years of age
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Central retinal artery equivalent (CRAE) Central retinal vein equivalent (CRVE) and Serum PLGF Level before 12Timepoint: between 11-20 weeks GA | — |
Secondary
| Measure | Time frame |
|---|---|
| Vessel density and tortuosity measured in terms of Presence of: arteriole narrowing, tortuosity, segmental retinal artery vasospasm, papilledema, serous retinal detachments, cotton wool spots and retinal hemorrhages Timepoint: Between 11-20 weeks of gestational age;Assessment of PlGF Blood Marker Testing in relation to Hands-on time, total turnaround time, rate of invalid results, device-related issues/malfunction and user satisfaction Timepoint: Between 11-20 weeks of gestational age;Delivery with Pre-eclampsiaTimepoint: Before 37 weeks Gestational Age;Health Care Utilization Outcomes which include: Number of antenatal visits, Referral to higher-level care, Self-reported use of aspirin & Self-reported use of calcium supplementation Timepoint: From pregnancy registration till delivery;Pre-eclampsia, Eclampsia, Maternal deathTimepoint: During enrolment and/or follow up period till discharge after delivery;Placental abruption, Severe maternal morbidity, Any Intensive care unit (ICU) admission; for more than 24 hours; duration of ICU admission, Intubation & mechanical ventilation (not for childbirth), Severe hypertension, Composite outcome on use of additional interventions for management of primary PPH (regardless of mode of birth) up until the end of the studyTimepoint: During enrolment and/or follow up period till discharge after delivery | — |
Countries
Ghana, India, Kenya, South Africa
Contacts
Public ContactDr Shivaprasad Goudar
Jawaharlal Nehru Medical College
Outcome results
None listed