Comparative Evaluation of Sutures Coated with Medicament Versus Plain Silk Sutures in Periodontal Flap Surgery

Comparative Evaluation of Antimicrobial Coated Versus Non-Coated Silk Sutures in Periodontal Flap Surgery: A Randomized Controlled Trial - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/04/107653

Enrollment

Registered

2026-04-06

Start date

Unknown

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Ciprofloxacin loaded with gold nanoparticles coated 3-0 silk suture in periodontal flap surgery and Ciprofloxacin coated 3-0 silk suture in periodontal flap surgery.: Group A: [Cip

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients with age group between 25-50 years of age. 2. Patients indicated for periodontal flap surgery (more than 5mm residual probing depth after Phase 1 therapy) 3. Systemically healthy patients.

Exclusion criteria

Exclusion criteria: 1. Patients with systemic diseases and those on medication for the same. 2. Pregnant and/or lactating women. 3. Patients with deleterious oral habits such as smoking or tobacco use. 4. Patients with any known allergy to Ciprofloxacin. 5. Patients who have received antibiotics in any form or have undergone major surgical procedures and received antibiotic therapy for the same within the past 3 months. 6. Patients unwilling to participate in the study or those not willing to comply with the follow-up schedule.

Design outcomes

Primary

Measure	Time frame
To evaluate and compare the clinical healing, plaque accumulation, and microbial colonization associated with ciprofloxacin-loaded gold nanoparticle coated (CPG-NP), ciprofloxacin-coated and non-coated 3-0 silk sutures following periodontal flap surgery.Timepoint: Assessing the clinical healing on 8th day ,plaque accumulation on 8th day, and microbial colonization on 8th day associated with ciprofloxacin-loaded gold nanoparticle coated (CPG-NP), ciprofloxacin-coated and non-coated 3-0 silk sutures following periodontal flap surgery.	—

Measure

Time frame

To evaluate and compare the clinical healing, plaque accumulation, and microbial colonization associated with ciprofloxacin-loaded gold nanoparticle coated (CPG-NP), ciprofloxacin-coated and non-coated 3-0 silk sutures following periodontal flap surgery.Timepoint: Assessing the clinical healing on 8th day ,plaque accumulation on 8th day, and microbial colonization on 8th day associated with ciprofloxacin-loaded gold nanoparticle coated (CPG-NP), ciprofloxacin-coated and non-coated 3-0 silk sutures following periodontal flap surgery.

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Secondary

Measure	Time frame
To assess & compare postoperative pain following the use of ciprofloxacin-loaded gold nanoparticle coated (CPG-NP), ciprofloxacin-coated & non-coated 3-0 silk sutures in periodontal flap surgery.Timepoint: postoperative pain assessment on 8th day following the use of ciprofloxacin-loaded gold nanoparticle coated (CPG-NP), ciprofloxacin-coated & non-coated 3-0 silk sutures following periodontal flap surgery.	—

Measure

Time frame

To assess & compare postoperative pain following the use of ciprofloxacin-loaded gold nanoparticle coated (CPG-NP), ciprofloxacin-coated & non-coated 3-0 silk sutures in periodontal flap surgery.Timepoint: postoperative pain assessment on 8th day following the use of ciprofloxacin-loaded gold nanoparticle coated (CPG-NP), ciprofloxacin-coated & non-coated 3-0 silk sutures following periodontal flap surgery.

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Countries

India

Contacts

Public ContactDr Lalitha Shiggaon

JMFs ACPM Dental College

drlalithavk@gmail.com8408876666

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026