Comparative Evaluation Of Human Amniotic Membrane And Chitosan Based Scaffold (VELNEZ ) On Periapical Healing Following Apicoectomy Using CBCT.

Comparative Evaluation Of Periapical Healing Following Apicoectomy Using LASER Alone, Human Amniotic Membrane With LASER, And Chitosan Based Resorbable Scaffold (VELNEZ) With LASER Using CBCT Assessment: A Randomized Controlled Clinical Trial. - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/04/107587

Enrollment

Registered

2026-04-06

Start date

Unknown

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K048- Radicular cyst

Interventions

Intervention1: LASER Biostimulation Following Apicoectomy.: Following Standard Apicoectomy Procedure Including Flap Reflection, Osteotomy, Curettage, Root-End Resection And Retrograde Filling With MTA

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients aged between 18 and 50 years. 2. Endodontically treated teeth with persistent periapical lesion requiring apicoectomy. 3. Lesion size between 5 mm and 10 mm. 4. Patients medically fit for minor oral surgery (ASA I or II). 5. Patients willing to provide written informed consent and comply with follow-up schedule.

Exclusion criteria

Exclusion criteria: 1. Pregnant or lactating females. 2. Periodontally compromised teeth. 3. Vertical root fracture. 4. Lesion size greater than 10 mm. 5. Patients allergic to shellfish (possible chitosan sensitivity). 6. Patients unwilling to participate or unable to attend follow-up visits.

Design outcomes

Primary

Measure	Time frame
Evaluation Of Periapical Bone Healing Following Apicoectomy Among The Three Treatment Groups And Reduction In Lesion Size.Timepoint: 1 Week After Surgery	—

Secondary

Measure	Time frame
Radiographic healing evaluated using intraoral periapical radiographs and CBCT Done Only After 12 Months.Timepoint: At 3, 6 And 12 Months.	—

Countries

India

Contacts

Public ContactDr Manju Kumari

I.T.S Dental College Hospital and Research Centre

dr.manjukumari.dntl.gn@its.edu.in9811056881

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026