Health Condition 1: K00-K95- Diseases of the digestive system
Conditions
Interventions
Intervention1: Intraoperative administration of dexmedetomidine at two different infusion doses, compared with placebo.: Patients receive intraoperative infusion of dexmedetomidine at 0.6 g/kg/hr or
Sponsors
DIVYA ARORA
Eligibility
Inclusion criteria
Inclusion criteria: 1 Adult patients undergoing elective open abdominal surgery lasting for more than 2 hours 2 Diagnosed anemia- Hemoglobin less than 11 gm dl for females, less than 12gm dl for males 3 ASA physical status I-III.
Exclusion criteria
Exclusion criteria: 1 Preexisting cognitive impairment or neurological disorders 2 Severe hepatic renal or cardiac dysfunction 3 Known allergy or contraindication to dexmedetomidine 4 Emergency surgeries 5 Patients who refuse consent 6 High delirium risk at baseline (4AT score more than or equal to 4) 7 Baseline bradycardia (HR less than 60 per min)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence and severity of postoperative delirium (POD score)Timepoint: 24 hours after surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence and severity of postoperative delirium (POD)Timepoint: Day 3 and 5 after surgery;Safety and hemodynamic stability of dexmedetomidine at varying doses in this patient population.Timepoint: Every hour during the surgery;Exploring the relationship between high and low doses of dexmedetomidine (mcg/kg/hour) administered intraoperatively and POD outcomesTimepoint: ;Any intraoperative or postoperative complicationsTimepoint: | — |
Countries
India
Contacts
Public ContactDivya Arora
IGIMS
Outcome results
None listed