A Study in Dental Implant Patients Comparing Hyaluronic Acid and Collagen to See Which Helps Gums Heal Better and Improves Bone Support Around Implants

Comparative evaluation of the efficacy of hyaluronic acid or collagen on peri-implant soft tissue attachment and osseointegration of titanium dental implants-a randomized clinical trial - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/04/107499

Enrollment

Registered

2026-04-02

Start date

Unknown

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Hyaluronic acid: HYALURONIDASE INJECTION IP 1500IU Intervention2: collagen: QUORO FIBRE Control Intervention1: hyaluronic acid & collagen: HYALURONIDASE INJECTION IP 1500IU ,QUORO FIBRE

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patient with age group between 18-65 years. 2. Patients who are cooperative, motivated, and have good oral hygiene. 3. Patients with no acute infection. 4. Patients with sufficient bone level at the site of conventional implant placement. 5. Patients who are willing and will be available for recall and follow-ups. 6. Absence of periodontal disease.

Exclusion criteria

Exclusion criteria: 1. Patients with any known systemic disease/conditions and/or on medication known to interfere with wound healing. 2. Patients who are current/ex- smokers or consume any other form of tobacco. 3. Patients with parafunctional habits and traumatic occlusion. 4. Teeth with periapical pathologies. 5. Pregnant or breastfeeding patients. 6. Patients with history of bone grafts or other regenerative procedures.

Design outcomes

Primary

Measure	Time frame
1. Implant stability 2. Tissue biotype assessment 3. Radiographic evaluation (standardized periapical grid radiographs)Timepoint: Baseline, 4 weeks ,12 weeks and 24 weeks	—

Secondary

Measure	Time frame
1. Plaque index (PI) 2. Gingival index (GI) 3. Peri-implant probing depth (PPD) 4. Relative clinical attachment level (r-CAL)Timepoint: Baseline, 4 weeks ,12 weeks & 24 weeks	—

Countries

India

Contacts

Public ContactDr Apoorva Chhabra

J.N Kapoor DAV(c) Dental College

drnymphea68@gmail.com9416493962

Outcome results