Comparison of three different doses of injection dexmedetomidine to attenuate stress response to endotracheal intubation for patients posted under general anaesthesia

Comparison of three different doses of nebulized dexmedetomidine to attenuate adrenergic response to laryngoscopy and intubation under general anaesthesia- A prospective randomized clinical study - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/04/107498

Enrollment

249

Registered

2026-04-02

Start date

Unknown

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Nebulized Dexmedetomidine Dose- 1: 0.6 g/kg of dexmedetomidine, diluted with 0.9% normal saline to form a total volume of 5 ml, will be given via nebulization mask over 10-15 mins in 1

Eligibility

Inclusion criteria

Inclusion criteria: ASA I and II posted for surgery under general anaesthesia requiring endotracheal intubation

Exclusion criteria

Exclusion criteria: Patient refusal, ASA III or IV, Patients with severe respiratory (pre-operative SpO2 less than 95), cardiac, liver or renal disorders, Anticipated difficult intubation or requiring more than 20 s or two attempts at laryngoscopy, Heart rhythms other than sinus, Patients on pre-operative medications that affect the heart rate like clonidine and beta-blockers, Patients on any sedatives, antipsychotics, antidepressants, anxiolytics, and anticonvulsants, Haemodynamically unstable patients, Pregnant patients, Known allergy to dexmedetomidine

Design outcomes

Primary

Measure	Time frame
To compare the changes in mean arterial pressure (MAP) at various time points after intubation from the baseline values among the three groups. Timepoint: At 1, 3, 5 and 10 mins after intubation	—

Secondary

Measure	Time frame
1. To compare the changes in heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) from baseline at various time points (1, 3, 5 and 10 mins after intubation). 2. To observe the maximum sedation score after nebulization in each group. 3. To observe any other associated adverse effects (bradycardia, hypotension etc.) 4. To compare the amount of propofol used for induction. Timepoint: 1, 3, 5 and 10 mins after intubation	—

Measure

Time frame

1. To compare the changes in heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) from baseline at various time points (1, 3, 5 and 10 mins after intubation). 2. To observe the maximum sedation score after nebulization in each group. 3. To observe any other associated adverse effects (bradycardia, hypotension etc.) 4. To compare the amount of propofol used for induction. Timepoint: 1, 3, 5 and 10 mins after intubation

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Countries

India

Contacts

Public ContactDr Kriti Chaudhary

AIIMS, Rajkot

kritisms@gmail.com9785036006

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026