Health Condition 1: D508- Other iron deficiency anemias
Conditions
Interventions
Intervention1: Hepcidin guided oral iron therapy: In one group Serum hepcidin will be tested and low hepcidin group will receive daily iron and high hepcidin group will receive alternate day iron.
In
Sponsors
All India Institute of Medical Sciences, Madurai, Tamil Nadu
Eligibility
Inclusion criteria
Inclusion criteria: Adults between 18 to 60 years with confirmed IDA (Hb less than 13 g per dL in males, less than 12 g per dL in females ferritin less than 30 ng per mL or ferritin between 30 and 100 ng per mL with TSAT less than 20) will be included.
Exclusion criteria
Exclusion criteria: Chronic kidney disease stage less than 3 (eGFR less than 60 mL per min per 1.73 m ) Decompensated chronic liver disease Known hemoglobinopathies Pregnancy or lactation Recent blood transfusion (within 4 weeks) Active infection/inflammation Use of parenteral iron in last 3 months Ongoing oral iron supplements
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in hemoglobin (Hb, g/dL) from baseline to 8 weeks. Iron indices, hepcidin correlation and change, adherence, GI side effects, responder proportion, and cost-effectiveness. Timepoint: At baseline, 4 weeks and 8 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Iron indices, hepcidin correlation & change, adherence, GI side effects, responder proportion, & cost effectiveness. Timepoint: At baseline, 4 weeks & 8 weeks | — |
Countries
India
Contacts
Public ContactDr Konnepati Sushma
All India Institute of Medical Sciences, Madurai, Tamil Nadu
Outcome results
None listed