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Comparing analgesic medications dexmedetomidine and ketamine and their combination in three different groups during surgery for pain relief after surgery

Comparison of dexmedetomidine, low-dose ketamine, and combination dexmedetomidine-ketamine infusion for postoperative analgesia in laparoscopic cholecystectomy surgery. - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/04/107388
Enrollment
66
Registered
2026-04-01
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K808- Other cholelithiasis

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: Nil: Nil

Sponsors

Shubha M R
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. American Society of Anaesthesiologists 1 and 2 of either sex 2. Aged between 18 and 65 years 3. Patients undergoing elective laparoscopic cholecystectomy surgery 4. Valid written informed consent

Exclusion criteria

Exclusion criteria: 1. ASA 3 and 4 2. Known allergy to ketamine or dexmedetomidine 3. History of liver or renal disease 4. Patients on chronic beta blocker treatment with a low baseline heart rate 5. Pregnancy 6. Increased intraocular pressure 7. Uncontrolled hypertension 8. Increased intracranial pressure 9. History of psychosis, seizure disorder.

Design outcomes

Primary

MeasureTime frame
Total postoperative opioid consumption within the first 24 hoursTimepoint: Total postoperative opioid consumption within the first 24 hours—

Secondary

MeasureTime frame
VAS score Ramsay sedation score Hemodynamic stability Adverse effects- nausea and vomitingTimepoint: 1st hour, 2nd hour, 3rd hour, 4th hour, 5th hour, 6th hour, 8th hour, 10th hour, 12th hour and 24th hour.—

Countries

India

Contacts

Public ContactShubha M R

Kasturba Medical College, Mangalore

shubha.ramesh269@gmail.com9008968789

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026