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Role of Urinary NGAL and KIM-1 in Evaluating Obstruction Severity in Children with Unilateral Hydronephrosis

Evaluation of Urinary Biomarkers NGAL (Neutrophil Gelatinase-Associated Lipocalin) and KIM-1 (Kidney Injury Molecule-1) as a Diagnostic Tool in Varying Degrees of Outflow Obstruction in Children of Unilateral Hydronephrosis - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/04/107377
Enrollment
110
Registered
2026-04-01
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N29- Other disorders of kidney and ureter in diseases classified elsewhere

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: NIL: NIL

Sponsors

Research Section, All India Institute of Medical Sciences, New Delhi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All patients of unilateral hydronephrosis below 14 years of age

Exclusion criteria

Exclusion criteria: 1. Children with solitary functioning kidney 2. Patients with a renal calculus 3. Patients who have previously undergone surgery for PUJO 4. Patients with coexisting urological diseases like VUR, VUJO, Neurogenic bladder, Duplex system, etc. 5. Patients with associated comorbid conditions like Epilepsy, Asthma, Glomerulonephritis syndromes, autoimmune diseases, etc

Design outcomes

Primary

MeasureTime frame
To assess the diagnostic utility of urinary biomarkers NGAL and KIM-1 in differentiating obstructive hydronephrosis from non-obstructive hydronephrosis in children and controls, as detected in renal dynamic scan findings. Timepoint: 2 years—

Secondary

MeasureTime frame
To identify any difference in the levels of urinary NGAL and KIM-1 in urine samples of patients with unilateral PUJO classified into non-obstructive HDN, partial PUJO, and definite PUJO based on preset criteria. To ascertain the presence of and quantify NGAL and KIM-1 in urine samples of unilateral hydronephrosis. To identify any correlation between the levels of urinary NGAL and KIM-1 and cortical transit time, differential renal function, and antero-posterior diameter of the pelvis. Timepoint: 2 years—

Countries

India

Contacts

Public ContactDr Vishesh Jain

All India Institute of Medical Sciences, New Delhi

dr.vishesh79@gmail.com8860080432

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026