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A study to compare different treatment methods for improving mouth opening in patients with oral submucous fibrosis using intralesional injections, laser treatment and minor surgical procedure

Comparative evaluation of intralesional multidrug therapy alone and in combination with photobiomodulation and minimally invasive laser fibrotomy for oral submucous fibrosis - NILL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/04/107339
Enrollment
42
Registered
2026-04-01
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K135- Oral submucous fibrosis Health Condition 2: K135- Oral submucous fibrosis

Interventions

Intervention1: Dexamethasone, Hyaluronidase, placentrex: Group A will be given dexamethasone, hyaluronidase, placentrex injections Group B will be given dexamethasone, hyaluronidase, placentrex inject

Sponsors

Krishna VIshwa Vidyapeeth
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients of both genders between 18 to 50 years og age Patients with grade I and grade II oral submucous fibrosis No recent history of corticosteroids for the treatment of oral submucous fibrosis Patients willing for participating in the study and giving written informed consent

Exclusion criteria

Exclusion criteria: Patients with grade III and grade IV oral submucous fibrosis Patient with compromised systemic health problems Patient not willing to participate in the study Patients who have already received any treatment

Design outcomes

Primary

MeasureTime frame
To evaluate the improvement of mouth opening in patients with oral submucous fibrosisTimepoint: 1 week, 5 weeks and 8 weeks—

Secondary

MeasureTime frame
NILTimepoint: NIL—

Countries

India

Contacts

Public ContactDr Nerita Bharat Patil

Krishna Vishwa Vidyapeeth

drmouneshkumarchapi07@gmail.com7709307635

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026