Health Condition 1: C148- Malignant neoplasm of overlappingsites of lip, oral cavity and pharynx Health Condition 2: C349- Malignant neoplasm of unspecifiedpart of bronchus or lung
Conditions
Interventions
Intervention1: Copper sixty four ATSM PET CT
: Hypoxia imaging tracer
for a total duration of eighteen months
Control Intervention1: Fluorodeoxyglucose PET CT : Standard metabolic imaging
for a total
Sponsors
Army Hospital Research and Referal
Eligibility
Inclusion criteria
Inclusion criteria: Patients older than 18 years with biopsy proven advanced stage head and neck carcinoma or non small cell lung cancer who are candidates for radiotherapy or chemotherapy and willing to give written informed consent
Exclusion criteria
Exclusion criteria: Pregnant or breastfeeding patients. Patients with poor glycaemic control. Patients unable to undergo PET CT scan. Patients unwilling to give written informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progression free survival assessed as time from diagnosis to disease progression, relapse or death from any causeTimepoint: At 6 months 12 months and 18 months after baseline | — |
Secondary
| Measure | Time frame |
|---|---|
| Maximum standardized uptake value of Copper sixty four ATSM & Fluorodeoxyglucose PET CT Timepoint: At Baseline;Correlation of tracer uptake parameters including SUV max SUV mean hypoxic tumor volume & hypoxic burden with progression free survival Timepoint: At 6 months 12 months & 18 months after baseline;Qualitative patterns of tracer uptake including homogeneous central marginal peripheral focal or no uptakeTimepoint: At Baseline | — |
Countries
India
Contacts
Public ContactBraj Kishore Singh
Army Hospital RR Delhi
Outcome results
None listed