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A study comparing how well different root canal medicaments kill germs in patients aged 18 to 50 years.

Comparative evaluation of antimicrobial efficacy of various intracanal medicaments against Enterococcus faecalis in patients aged 18 to 50 years: A randomized controlled trial. - NIL

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/04/107300
Enrollment
24
Registered
2026-04-01
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K041- Necrosis of pulp

Interventions

Intervention1: Modified Triple Antibiotic Paste: In modified triple antibiotic paste, clindamycin replaces minocycline. Clindamycin, ciprofloxacin and metronidazole mixed in ratio of 1:1:1 with steril

Sponsors

Dr Ajeeta Bhavsar
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1)Patients having age between 18 and 50 years irrespective of any gender. 2) Systemically healthy and co-operative patients will be selected. 3) Mandibular permanent premolars having deep caries approaching pulp radiographically. These teeth were diagnosed clinically as having necrotic or infected pulp and indicated for root canal treatment. 4) Mandibular premolars that exhibited carious involvement but had no prior history of restorations.

Exclusion criteria

Exclusion criteria: 1) Patients having any developmental anomalies of teeth. 2) Tooth having presence of a swelling or a sinus tract adjacent to the involved tooth, tenderness on percussion, pathologic tooth mobility, excessive hemorrhage from exposure site indicating progressive inflammation. 3) Tooth with internal resorption as well external resorption as seen on radiograph. 4) Cases requiring retreatment. 5) Individuals on antibiotic therapy within the three months leading up to the study; teeth. 6) Teeth with calcified canals, immature apex, periapical lesions.

Design outcomes

Primary

MeasureTime frame
mean reduction in bacterial count of Enterococcus faecalis in rot canals after 7 days of placement of intracanal medicaments, comparing 3 groupsTimepoint: mean reduction in bacterial count of Enterococcus faecalis in rot canals after 7 days of placement of intracanal medicaments, comparing 3 groups

Secondary

MeasureTime frame
NILTimepoint: NIL

Countries

India

Contacts

Public ContactDr Ajeeta Bhavsar

Mgvs KBH Dental College and Hospital Panchavati Nashik Maharashtra 422003

meenalgulve@gmail.com9822602043

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026