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A Study to correlate non-invasive Carotid artery ultrasound with fluid responsive index (Pulse Pressure Variation) to guide fluid management during prone position spine surgery

Correlation of non-invasive carotid doppler indices with pulse pressure variability based goal-directed hemodynamic therapy in prone-position thoracolumbar and lumbar neurosurgical procedures: a prospective observational study - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/04/107263
Enrollment
62
Registered
2026-04-01
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: D321- Benign neoplasm of spinal meninges Health Condition 2: M51- Thoracic, thoracolumbar, and lumbosacral intervertebral disc disorders Health Condition 3: A180- Tuberculosis of bones and joints

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: Nil: Nil

Sponsors

Govind Ballabh Pant Institute of Postgraduate Medical Education and Research
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All ASA (American Society of Anaesthesiology) physical status I & II patients, scheduled for elective thoracolumbar and lumbar spine surgery in the prone position.

Exclusion criteria

Exclusion criteria: Impaired left ventricular function (ejection fraction less than 50%). Moderate to severe valvular disease. ECG Rhythm disturbance. Carotid artery disease or stenosis more than 50%. Basal Metabolic Index (BMI) more than 30 or less than 15 kg m2 History of cerebrovascular accident or transient ischemic attack. Respiratory system disease affecting lung compliance Inability to obtain adequate Carotid Doppler signals. Severe peripheral arterial occlusive disease

Design outcomes

Primary

MeasureTime frame
Change in FTc and Change in CDPV to fluid bolus Change in PPV to fluid bolus Correlation between FTc and Change in CDPV with PPV Timepoint: 1.5 min after induction (supine)- Baseline. 2.5 min after completion of fluid loading. 3.10 min after stabilisation in prone position and check for fluid responsiveness. 4.5 min after 2nd fluid loading (if responsive) in prone position. 5.Every hour intraoperatively. 6.After completion of surgery, patient in the prone position. 7.5min after making the patient supine.—

Secondary

MeasureTime frame
Resistivity Index (RI) trends across intraoperative phaseTimepoint: 1.5 min after induction (supine)- Baseline. 2.5 min after completion of fluid loading. 3.10 min after stabilisation in prone position and check for fluid responsiveness. 4.5 min after 2nd fluid loading (if responsive) in prone position. 5.Every hour intraoperatively. 6.After completion of surgery, patient in the prone position. 7.5min after making the patient supine.—

Countries

India

Contacts

Public ContactDr KIRAN LATA KIRO

Govind Ballabh Pant Institute of Postgraduate Medical Education and Research

kirankiro@gmail.com9718592450

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026