To study how anaesthetic agents (ketamine, combined with dexmedetomidine) can alter mood and thoughts and reduce the need for painkillers in patients undergoing Breast Surgery.

To compare the analgesic efficacy and positive psychedelic symptoms of different doses of ketamine in combination with dexmedetomidine in patients undergoing opioid-sparing Breast cancer Surgery (BCS) - nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/04/107230

Enrollment

Registered

2026-04-01

Start date

Unknown

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C50- Malignant neoplasm of breast

Interventions

Intervention1: Ketamine infusion group: Ketamine infusion will be started at 0.25mg kg-1, 0.5mg kg-1 and 1mgkg-1 after standard induction according to the groups allotted. Infusion will be stopped at

Eligibility

Inclusion criteria

Inclusion criteria: ASA1,2 BMI 18 35 kg/m2

Exclusion criteria

Exclusion criteria: H/o epilepsy Raised ICT 1. Pre-op antipsychotic medication history 2. Uncontrolled hypertension 3. Allergy 4. AV block patients, cardiac ailments, low EF 5. Glaucoma, previous ocular surgery

Design outcomes

Primary

Measure	Time frame
postoperative pain intensity measured by VAS score, intraoperative opioid requirement, incidence and severity of positive psychedelic symptoms.Timepoint: 1.T1 baseline assessment of CADSS 2. T2 Postoperative pain intensity measured by VAS score, intraoperative opioid requirement, severity of positive psychedelic symptoms. T3- VAS score and severity of positive psychedelic symptom 2hours after surgery	—

Measure

Time frame

postoperative pain intensity measured by VAS score, intraoperative opioid requirement, incidence and severity of positive psychedelic symptoms.Timepoint: 1.T1 baseline assessment of CADSS 2. T2 Postoperative pain intensity measured by VAS score, intraoperative opioid requirement, severity of positive psychedelic symptoms. T3- VAS score and severity of positive psychedelic symptom 2hours after surgery

—

Secondary

Measure	Time frame
To compare the recovery profile using the modified Aldrete score ,Sedation score using Ramsay sedation scale Haemodynamic variability between the groups Postoperative patient s satisfaction using Likert s scale To record presence of nystagmus, diplopia or headache and PONV Timepoint: At extubation and one hour postoperative	—

Countries

India

Contacts

Public ContactDr.Soumi Pathak

Rajiv Gandhi Cancer Institute and Research Center

pathaksoumi@gmail.com09891620042

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026