Effect of Bone Graft with and without Fisetin Gel in Treating Bone Defect: A Clinical Trial

Comparative Evaluation of Demineralized Freeze-Dried Bone Allograft with and without fisetin gel in the treatment of Class II Furcation Defects: A Randomized Controlled Trial. - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/03/107142

Enrollment

Registered

2026-03-30

Start date

Unknown

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K088- Other specified disorders of teethand supporting structures

Interventions

Intervention1: Fisetin Gel with DFDBA: Stage III Periodontitis aged 30 to 60 patients exhibiting 25 Class II furcation defects to be treated with Fisetin gel with DFDBA intervention frequency one time

Eligibility

Inclusion criteria

Inclusion criteria: 1 Patients with Stage III periodontitis as assessed by Probing Pocket Depth more than equal to 6mm, interdental Clinical Attachment Level more than equal to 5 mm and Horizontal Probing Depth more than equal to 2mm. 2 Presence of bilateral Class II furcation defects.

Exclusion criteria

Exclusion criteria: 1 Patients with history of systemic diseases, allergies or drug usage 2 Patients who have undergone periodontal treatment in previous 6 months 3 Pregnant and lactating females 4 Smokers or tobacco chewers

Design outcomes

Primary

Measure	Time frame
Toevaluate and compare the effectiveness of DFDBA with or without fisetin gel in treatment of class II furcation defect clinically and radiographicallyby CBCTTimepoint: At baseline , 3 month , 6 month	—

Secondary

Measure	Time frame
1 To evaluate Clinical Attachment Level (CAL), Probing Pocket Depth (PPD) and Horizontal Probing Depth (HPD) in Class II furcation defects when treated with Fisetin gel in combination with DFDBA and DFDBA alone at baseline, 3- and 6-months post operatively. 2. To evaluate radiographic bone fill obtained in Class II furcation defects when treated with fisetin gel in combination with DFDBA and DFDBA alone at baseline and 6 months post operatively by CBCT. 3. To Compare Clinical Attachment Level (CAL), Probing Pocket Depth (PPD) and Horizontal Probing Depth (HPD) in Class II furcation defects when treated with Fisetin gel in combination with DFDBA and DFDBA alone at baseline, 3- and 6-months post operatively. 4. To compare radiographic bone, fill in Class II furcation defects when treated with Fisetin gel in combination with DFDBA and DFDBA alone at baseline and 6 months post operatively by CBCT. Timepoint: At baseline ,3 month ,6 month	—

Measure

Time frame

1 To evaluate Clinical Attachment Level (CAL), Probing Pocket Depth (PPD) and Horizontal Probing Depth (HPD) in Class II furcation defects when treated with Fisetin gel in combination with DFDBA and DFDBA alone at baseline, 3- and 6-months post operatively. 2. To evaluate radiographic bone fill obtained in Class II furcation defects when treated with fisetin gel in combination with DFDBA and DFDBA alone at baseline and 6 months post operatively by CBCT. 3. To Compare Clinical Attachment Level (CAL), Probing Pocket Depth (PPD) and Horizontal Probing Depth (HPD) in Class II furcation defects when treated with Fisetin gel in combination with DFDBA and DFDBA alone at baseline, 3- and 6-months post operatively. 4. To compare radiographic bone, fill in Class II furcation defects when treated with Fisetin gel in combination with DFDBA and DFDBA alone at baseline and 6 months post operatively by CBCT. Timepoint: At baseline ,3 month ,6 month

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Countries

India

Contacts

Public ContactDR DHAWAL MODY

Ranjeet Deshmukh dental college and research center

periowell@gmail.com8055775977

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026