Comparing Two Combination Treatments for Melasma: Tranexamic Acid Gel with Microneedling vs. Tranexamic Acid Gel with Laser Therapy.

TO COMPARE THE EFFICACY OF SYNERGISTIC EFFECT OF 5% TOPICAL TRANEXAMIC ACID GEL WITH MICRONEEDLING VS 5% TOPICAL TRANEXAMIC ACID GEL WITH Q-SWITCHED ND: YAG LASER FOR THE TREATMENT OF MELASMA - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/03/107126

Enrollment

Registered

2026-03-30

Start date

Unknown

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L00-L99- Diseases of the skin and subcutaneous tissue

Interventions

Intervention1: TOPICAL 5 % TRANEXAMIC ACID GEL WITH MICRONEEDLING: Microneedling performed using dermapen followed by topical application of 5 % tranexamic acid daily at night for treatment of melasma

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients aged 18-60 years with facial melasma of more than or equal to 3 months duration 2. Follow up regularly 3. Not currently on any systemic or procedural melasma treatment in past 3 months

Exclusion criteria

Exclusion criteria: 1. Pregnancy or lactation 2. History of keloid or hypertrophic scar 3. Active skin infections 4. Photosensitizing medication use 5. Use of oral tranexamic acid 6. History of bleeding disorder 7. Immunocompromised patients 8. Allergy to TXA

Design outcomes

Primary

Measure	Time frame
1. Improvement in mMASI score 2. Dermoscopy melasma score 3. Recurrence rate after treatment Timepoint: FROM 0 TO 14 WEEKS	—

Secondary

Measure	Time frame
1.Patient satisfaction score on five-point Likert scale. 2. Side effects- Erythema, pain, PIH, dryness. 3.Procedure tolerance and downtime.Timepoint: 0 to 14 weeks	—

Countries

India

Contacts

Public ContactDR SAURABH SHARMA

sri guru ram das institute of medical sciences and research, sri amritsar

drsaurabhsharma@yahoo.co.in9815162491

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026