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A interventional study comparing recovery from anesthesia using Neostigmine alone versus Neostigmine with additional dose of Sugammadex in patients receiving general anesthesia with Vecuronium.As using Sugammadex may reduce incidence of residual neuromuscular block more effectively than Neostigmine

Randomized controlled study comparing the efficacy of reversal with Neostigmine alone versus Neostigmine plus an additional dose of Sugammadex in general anesthesia using Vecuronium. - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/03/107098
Enrollment
80
Registered
2026-03-30
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K00-K95- Diseases of the digestive system Health Condition 2: N00-N99- Diseases of the genitourinary system Health Condition 3: Z00-Z99- Factors influencing health status and contact with health services

Interventions

Intervention1: Neostigmine: 0.05 mg/kg Intervention2: Neostigmine plus Sugammadex: 0.05 mg/ kg plus 1 mg/ kg Intervention3: Neostigmine plus sugammadex: 0.05 mg/kg intravenous stat plus 1mg/kg intrav

Sponsors

Jagjivan Ram Railway hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA Physical status 1-3, Undergoing elective surgery under General anesthesia, Informed written consent

Exclusion criteria

Exclusion criteria: Either suspected or known case of neuromuscular disorder,Severe renal or hepatic dysfunction,history of Malignant Hyperthermia,Allergy to study medication,patient with known case of difficult airway,Hyperkalemia,History of stroke,Glaucoma,Pregnant or breast feeding women,use of interacting drugs(anticonvulsant drug,magnesium,aminoglycosides)

Design outcomes

Primary

MeasureTime frame
Incidence of residual neuromuscular blockageTimepoint: Incidence of residual neuromuscular blockage at time of extubation—

Secondary

MeasureTime frame
Time from reversal agent to TOF equal or greater than 0.9Timepoint: At time of extubation;Time from giving reversal agent to extubationTimepoint: 3 minutes;Time to operation dischargeTimepoint: Discharging patient after extubation;Incidence of adverse eventsTimepoint: ;Clinical recovery parametersTimepoint:—

Countries

India

Contacts

Public ContactDR SHIVAM RUPAM

Jagjivan ram railway hospital

drdksahujrh@gmail.com9004490532

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026