Effect of Probiotics with Methotrexate on Psoriasis

Efficacy of probiotics as an adjunctive therapy with oral methotrexate in chronic plaque psoriasis : a randomized controlled trial - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/03/107054

Enrollment

Registered

2026-03-30

Start date

Unknown

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L400- Psoriasis vulgaris

Interventions

Intervention1: probiotics along with methotrexate: patient is started on weekly once methotrexate along with daily intake of probiotics Control Intervention1: only methotrexate weekly once (0.3 mg / k

Eligibility

Inclusion criteria

Inclusion criteria: patients diagnosed as psoriasis and pasi greater than 10

Exclusion criteria

Exclusion criteria: 1. patient taken any local or systemic treatment in past 6 weeks 2.suffering from any other variant of psoriasis 3.hepatic , renal impairment 4.pregnant , lactating mothers 5.active infections 6.smokers / chronic alcoholic

Design outcomes

Primary

Measure	Time frame
PASI scoring evaluatedTimepoint: week 0 week 4 week 8 week 12	—

Secondary

Measure	Time frame
CRP , LIPID PROFILE , N/L RATIO ,DLQI ASSESSEDTimepoint: week 0 week 4 week 8 week 12	—

Countries

India

Contacts

Public ContactDr Suhani Bothra

KIMS hospital

drdbehera427@gmail.com9692188333

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026