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Effect of Oral Collagen on Skin Health in Healthy Adults

A Randomized, Double-Blind, Placebo-Controlled Subject-Based Clinical Study to Evaluate the Efficacy of Liposomal Collagen (LipoLushTM) Supplementation on Skin Health in Healthy Adults - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/03/107036
Enrollment
60
Registered
2026-03-30
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Liposomal Collagen (LipoLushTM): Dose: 7 g Each sachet contain 5 g of liposomal collagen (LipoLush ) will be reconstituted in 150 200 mL of water and consumed orally once daily after

Sponsors

Botanic Healthcare Pvt. Ltd.
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Healthy adults aged equal to or more than 18 years. 2.In good general health based on medical history. 3.Visible crow s feet wrinkles (grade equal to or greater than 2). 4.Willing to avoid other collagen or skin-related supplements during the study. 5.Willing to use only the skincare products provided in the study. 6.Able and willing to provide written informed consent.

Exclusion criteria

Exclusion criteria: 1.Pregnant or lactating women. 2.Recent facial dermatologic procedures (laser, chemical peel, fillers, botulinum toxin). 3.Active facial skin disorders. 4.Known allergy or hypersensitivity to collagen. 5.Participation in another clinical trial within the past 30 days. 6.Vegan or vegetarian diet restricting animal-derived collagen.

Design outcomes

Primary

MeasureTime frame
1. Skin elasticity measured using a Cutometer. 2. Crow s feet wrinkle count assessed by blinded dermatologist using standardized facial photography (with optional ImageJ analysis). Timepoint: Baseline, Week 4 and Week 8—

Secondary

MeasureTime frame
Wrinkle depth and area assessed by blinded dermatologist with standardized photography (optional ImageJ analysis). Timepoint: Baseline, Week 4 and Week 8;Skin hydration measured using a Corneometer.Timepoint: Baseline, Week 4 and Week 8;Skin colour parameters (pigmentation and erythema) measured using a Mexameter.Timepoint: Baseline, Week 4 and Week 8;Subjective skin improvement assessed using a self-reported questionnaire.Timepoint: Baseline, Week 4 and Week 8;Plasma collagen-derived peptides measured by validated LC MS.Timepoint: Baseline and Week 8;Serum P1NP levels measured by ELISA as a marker of collagen synthesis.Timepoint: Baseline and Week 8—

Countries

India

Contacts

Public ContactDr H N Shivaprasad

Botanic Healthcare Pvt. Ltd.

research1@botanichealthcare.net7995688815

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026