A study to evaluate the effect of nutraceutical supplementation on skin darkening in people

A Case Series to Evaluate the Effects of Nutrova Melatace on Hyperpigmentation in Acanthosis Nigricans - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Observational

Source

CTRI

Registry ID

CTRI/2026/03/107014

Enrollment

Registered

2026-03-27

Start date

Unknown

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Nutrova Melatace: 1 capsule daily, orally, after any meal for 60 days. Control Intervention1: NA: NA

Eligibility

Inclusion criteria

Inclusion criteria: Clinically diagnosed acanthosis nigricans Fitzpatrick skin types III to V Visible hyperpigmentation Willing to consume supplement daily for 60 days No cosmetic procedures in the last 6 months Not using new skincare/supplements affecting skin Willing to provide written informed consent

Exclusion criteria

Exclusion criteria: Known allergy to supplement ingredients Pregnant or breastfeeding women Participation in another clinical study within 30 days Use of retinoids, corticosteroids, antibiotics (past 3 months) Systemic illness affecting skin (except Type II diabetes) Diabetics with abnormal liver/kidney function Change in diabetes medication during study

Design outcomes

Primary

Measure	Time frame
Change in pigmentation severity using Acanthosis Nigricans Scoring Chart (ANSC) (colour, texture, size)Timepoint: Day 0, 30, 60	—

Secondary

Measure	Time frame
1) Improvement in ANSC parameters (colour, texture, size) 2) Standardized photographic assessment of affected area 3) Participant self-assessment questionnaire (Likert scale): a) The pigmentation in my affected area has reduced b) My skin texture in the affected area has improved c) My skin appears healthier d) I am satisfied with the improvement e) I am very satisfied with the results 4) Changes in HbA1c, fasting glucose, postprandial glucose (subset) Timepoint: For 1, 2: Day 0, Day 30, Day 60 For 3: Day 30, 60 For 4: Day 0, Day 60	—

Measure

Time frame

1) Improvement in ANSC parameters (colour, texture, size) 2) Standardized photographic assessment of affected area 3) Participant self-assessment questionnaire (Likert scale): a) The pigmentation in my affected area has reduced b) My skin texture in the affected area has improved c) My skin appears healthier d) I am satisfied with the improvement e) I am very satisfied with the results 4) Changes in HbA1c, fasting glucose, postprandial glucose (subset) Timepoint: For 1, 2: Day 0, Day 30, Day 60 For 3: Day 30, 60 For 4: Day 0, Day 60

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Countries

India

Contacts

Public ContactDr Meghna Motwani

Axys Nutrition Products Private Limited

meghna.motwani@nutrova.com9867144003

Outcome results