Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: ICG group: Patients in the intervention group will undergo McKeown minimally invasive esophagectomy with intraoperative indocyanine green (ICG) fluorescence imaging to assess gastric co
Sponsors
Basavatarakam Indo American Cancer Hospital and Research Institute
Eligibility
Inclusion criteria
Inclusion criteria: Adult patients 18 years to 75 years. Histologically confirmed carcinoma of the esophagus or gastroesophageal junction. Patients planned for McKeown minimally invasive esophagectomy with gastric conduit reconstruction and cervical esophagogastric anastomosis. Patients who may have received neoadjuvant chemotherapy or chemoradiotherapy as per institutional protocol. Resectable disease without distant metastasis on preoperative staging. Ability to provide written informed consent.
Exclusion criteria
Exclusion criteria: Refusal or inability to provide informed consent. Unresectable or metastatic disease detected during preoperative evaluation or intraoperatively. Patients considered high risk for esophagectomy due to severe cardiopulmonary comorbidity. Known allergy or hypersensitivity to indocyanine green or iodine. Pregnant or breastfeeding women. Severe renal or hepatic dysfunction contraindicating ICG use.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of anastomotic leak within 30 days after McKeown minimally invasive esophagectomy.Timepoint: Within 30 days postoperatively. | — |
Secondary
| Measure | Time frame |
|---|---|
| Perfusion assessment of gastric conduit and proximal esophageal stump using ICG fluorescence imaging compared with visual assessment.Timepoint: ;Rate of intraoperative modification of the anastomotic site based on perfusion findingsTimepoint: ;Time to fluorescence appearance and complete conduit enhancement after intravenous ICG injectionTimepoint: ;Postoperative morbidity within 30 days according to Clavein Dindo scaleTimepoint: Within 30 days postoperatively;Length of postoperative hospital stay (days)Timepoint: ;30-day postoperative mortalityTimepoint: | — |
Countries
India
Contacts
Public ContactSyed Nusrath
Basavatarakam Indo American Cancer Hospital and Research Institute
Outcome results
None listed