Comparison of diclofenac injection versus paracetamol plus diclofenac injections for pain relief after uterus removal surgery

Comparison of intravenous Diclofenac v/s intravenous Paracetamol and Diclofenac combination for postoperative analgesia in Total Abdominal Hysterectomy: A prospective randomised double-blind study - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/03/106993

Enrollment

Registered

2026-03-27

Start date

Unknown

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N939- Abnormal uterine and vaginal bleeding, unspecified Health Condition 2: N711- Chronic inflammatory disease of uterus Health Condition 3: N850- Endometrial hyperplasia Health Condition 4: N924- Excessive bleeding in the premenopausal period Health Condition 5: N74- Female pelvic inflammatory disorders in diseases classified elsewhere Health Condition 6: O9A1- Malignant neoplasm complicating pregnancy, childbirth and the puerperium Health Condition 7: C539- Malignant neopl

Interventions

Intervention1: Injection Diclofenac 75mg IV with Injection Paracetamol 1g IV: At the end of surgery, patient will receive 75mg of IV Diclofenac diluted in 10 ml of isotonic saline over 10min and 100 m

Eligibility

Inclusion criteria

Inclusion criteria: 1.Weight more than 45kgs 2. Height more than 138cm 3. ASA grade I and II. 4.Undergoing elective total abdominal hysterectomy under subarachnoid block.

Exclusion criteria

Exclusion criteria: 1. Patients who are not willing to participate in the study. 2.ASA grade III and IV 3.History of drug or alcohol abuse. 4. History of coagulation abnormalities. 5. Known hypersensitivity to any of study medication. 6. Patients on long term analgesics 7. Patients with contraindications to spinal anaesthesia

Design outcomes

Primary

Measure	Time frame
Time to request post-operative rescue analgesia (Ibuprofen) assessed using VAS scoresTimepoint: The VAS scores will be recorded at 0, 1, 2, 4, 6, 8, 12, 16, 18 and 24 hours	—

Secondary

Measure	Time frame
1. Total consumption of rescue analgesia (Ibuprofen) in 24 hours. 2. VAS (Visual Analogue Scale) score at rest and on movement for 24hrs postoperatively. 3. Episodes of nausea, retching and vomiting during the 24-hour postoperative period. 4. Overall patient satisfaction.Timepoint: The VAS scores will be recorded at 0, 1, 2, 4, 6, 8, 12, 16, 18 and 24 hours	—

Countries

India

Contacts

Public ContactDr Saroj Devasi

RNT MEDICAL COLLEGE UDAIPUR

dr.rgehlot.2010@gmail.com7023160126

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026