A comparison of healing after lower third molar surgery with blood clot, platelet rich fibrin and platelet rich fibrin with hydroxyapatite.

Comparative evaluation of healing of impacted mandibular third molar surgery with blood clot, platelet rich fibrin and platelet rich fibrin enriched with hydroxyapatite. - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/03/106987

Enrollment

Registered

2026-03-27

Start date

Unknown

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: -

Interventions

Intervention1: Healing of mandibular third molar surgery with Platelet Rich Fibrin (PRF): A randomized clinical trial will be conducted among 30 patients to evaluate the effect of blood clot, PRF and

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients with partially erupted or completely impacted mandibular impacted third molars. 2.Patients with impaction of similar Pederson difficulty index with moderate to difficult scores only and whose adjacent second molars are intact and well positioned. 3.Age group of 18 40 years. 4.Patient should be of ASA I category: healthy, non-smoking, non-alcoholic. 5.No contraindication for the local anesthetic that will be utilized in the surgical procedure. 6.Patients who are willing to accept informed consent and are willing to participate in the study with its subsequent follow-ups.

Exclusion criteria

Exclusion criteria: 1.Patients with completely erupted mandibular third molars. 2.Patients with habits like smoking, alcohol consumption. 3.Patients suffering from uncontrolled diabetes mellitus, tuberculosis, asthma and leukemia. 4.Patients having any abscess or any pathology in relation to impacted 3rd molars. 5.Patients below 18 years of age. 6.Pregnant and lactating women. 7.Patients coming under the category of ASA II, III, IV

Design outcomes

Primary

Measure	Time frame
The study result will help us to know whether blood clot, platelet-rich fibrin (PRF) or PRF enriched with hydroxyapatite will result in better osseous regeneration and periodontal healing after impacted mandibular third molar surgery.Timepoint: 3rd day, 7th day, 14th day, 1st month, 3rd month, 6th month	—

Secondary

Measure	Time frame
The study result will be helpful in use of PRF as an autologous graft material to fill larger bone defects and in other clinical applications and further research purpose.Timepoint: 3rd day, 7th day, 14th day, 1st month, 3rd month, 6th month	—

Countries

India

Contacts

Public ContactSudhashree Panda

Government Dental College, Raipur

mishra.biswajit08@gmail.com9893095190

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026