Health Condition 1: T632- Toxic effect of venom of scorpion
Conditions
Interventions
Intervention1: Chloroquine Phosphate (64.5mg/ml): Local infiltration/digital block with Injection Chloroquine Phosphate (64.5 mg/mL). Total dose 193.5 mg, equivalent to 120 mg of chloroquine base.
Fo
Sponsors
Jawaharlal Institute of Postgraduate medical education and research
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age more than or equal to 18 years and less than or equal to 85 years. 2. Presentation within 6 hours of a definite scorpion sting. 3. Localized pain (Grade I envenomation). 4. Moderate-to-severe pain intensity (Numerical Rating Scale (NRS) score more than or equal to 5/10).
Exclusion criteria
Exclusion criteria: 1. Evidence of systemic envenomation (Grade II or higher) requiring antivenom or ICU admission. 2. History of allergy or hypersensitivity to Chloroquine or amide local anesthetics. 3. Pregnancy or lactation (Urine pregnancy test for females of childbearing potential). 4. Known history of G6PD deficiency, retinopathy, psoriasis, or severe cardiac arrhythmia (e.g., prolonged QTc). 5. Receipt of any parenteral analgesia or local anesthetic prior to enrollment. 6. Local site infection or necrosis at the sting site
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the duration of effective analgesia (time to first request for rescue medication or recurrence of moderate pain) between the Chloroquine group and the Lidocaine group in patients with Scorpion stingTimepoint: NRS (Numerical rating scale) scores will be recorded at Baseline, 15minutes, 30minutes, 60minutes, 90minutes, 120(2hr)minutes, 150minutes, 180(3hr)minutes, 210minutes, 240(4hrs)minutes, 270minutes, 300(5hrs)minutes, 330minutes, 360 minutes, 8hrs, 10hrs, 12hrs and 24 hours. | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the Numerical Rating Scale (NRS) pain scores at predefined intervalsTimepoint: 15, 30, 60, 90, 120(2hr), 150, 180(3hr), 210, 240(4hrs), 270, 300(5hrs), 330, 360 minutes, 8hours, 10hours, 12hours and 24 hours after administration of drug;To compare the proportion of patients requiring rescue analgesia within 24 hoursTimepoint: From Administration of the drug to 24 hours after administration ;To assess the incidence of local and systemic adverse events.Timepoint: from administration of drug to 24 hours after administration of drug | — |
Countries
India
Contacts
Public ContactDr Manu Ayyan
Jawaharlal Institute of post graduate medical education and research
Outcome results
None listed