Health Condition 1: F322- Major depressive disorder, singleepisode, severe without psychotic features
Conditions
Interventions
Intervention1: VAJ Yoga Program: articipants in the intervention arm will receive a structured VAJ Yoga program in addition to standard medical treatment for depression. The VAJ Yoga program will cons
Sponsors
Pacific Medical College & Hospital, Pacific Medical University
Eligibility
Inclusion criteria
Inclusion criteria: Male and female participants aged 18 to 80 years diagnosed with major depressive disorder with Hamilton Depression Rating Scale score greater than or equal to 20 receiving standard treatment and willing to participate in VAJ Yoga intervention for 12 weeks and able to provide written informed consent with no regular yoga practice in the last 6 months.
Exclusion criteria
Exclusion criteria: Patients with severe psychiatric disorders other than depression (e.g., schizophrenia, bipolar disorder, psychosis). Patients with serious uncontrolled medical illnesses (e.g., severe cardiovascular disease, renal failure, liver disease, or malignancy). Patients with neurological disorders affecting participation or EEG interpretation. Patients with substance or alcohol dependence. Patients who have regularly practiced yoga or meditation within the last 6 months. Patients unable to participate in yoga sessions due to physical disability or severe illness. Patients unwilling or unable to provide written informed consent. Participants unlikely to complete the 12-week follow-up period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in DASS-42 total score (Depression + Anxiety + Stress subscales) from baselineTimepoint: Change in DASS-42 total score (Depression + Anxiety + Stress subscales) from baseline | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in HAM-D (Hamilton Depression Rating Scale) score from baselineTimepoint: Baseline (Week 0) and Week 12;Change in Oxford Happiness Questionnaire (OHQ) scoreTimepoint: Baseline (Week 0) and Week 12;Change in Emotional Quotient (EQ) score (NHS scale)Timepoint: Baseline (Week 0) and Week 12;Change in Spiritual Quotient (SQ) score (SISRI-24)Timepoint: Baseline (Week 0) and Week 12;Change in cognitive performance (WAIS-IV Digit Span / Working Memory index)Timepoint: Baseline (Week 0) and Week 12;Change in quantitative EEG band power (alpha, beta, theta, delta) in frontal, parietal and temporal regionsTimepoint: Baseline (Week 0) and Week 12;Change in serum serotonin concentrationTimepoint: Baseline (Week 0) and Week 12;Change in serum dopamine concentrationTimepoint: Baseline (Week 0) and Week 12 | — |
Countries
India
Contacts
Public ContactJeshurun Mathew James
Pacific Medical College and Hospital, Pacific Medical University
Outcome results
None listed