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A Study to Find Out If a Numbing Throat Spray Reduces Discomfort During Endoscopy in Sedated Adult Patient

Effect of Adding Topical Lignocaine Spray to Low-Dose Ketamine Versus Ketamine Alone on Patient Comfort and Adverse Events in Adults Undergoing Propofol-Sedated Upper Gastrointestinal Endoscopy: A Single-Centre Double-Blinded Randomised Controlled Trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/03/106873
Enrollment
992
Registered
2026-03-25
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K269- Duodenal ulcer, unspecified as acute or chronic, without hemorrhage or perforation Health Condition 2: K259- Gastric ulcer, unspecified as acute or chronic, without hemorrhage or perforation Health Condition 3: K210- Gastro-esophageal reflux disease with esophagitis Health Condition 4: K299- Gastroduodenitis, unspecified Health Condition 5: K221- Ulcer of esophagus Health Condition 6: K221- Ulcer of esophagus

Interventions

Intervention1: Propofol + Ketamine + Lignocaine 10% Spray: The patients oropharynx will be sprayed with four sprays of Lignocine 10% spray three minutes before induction with propofol. Then, 25 mg of

Sponsors

Pushpawati Singhania Hospital and Research Institute
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients of the age group 18 80 years undergoing upper GI endoscopy and patients with ASA physical status grade 1-3

Exclusion criteria

Exclusion criteria: Patients who refuse to give consent, patients with ASA physical status grade more than or equal to 4 and patients who undergo emergency upper GI endoscopy

Design outcomes

Primary

MeasureTime frame
Patient s throat discomfort scoreTimepoint: At 15 minutes post procedure—

Secondary

MeasureTime frame
Propofol requirementTimepoint: For entire procedure;Gag reflexTimepoint: During any time point while doing endoscopy;Adverse events like cough, desaturation, increase in secretions, bradycardia, hypotension & bleedingTimepoint: During any time point while doing endoscopy—

Countries

India

Contacts

Public ContactRagiri Surya Theja

Pushpawati Singhania Hospital and Research Institute

suryathejadr20@gmail.com07217742664

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026