A trial on the therapeutic effect of repetitive transcranial magnetic stimulation (rTMS) as add-on treatment in mild-moderate dementia patients

Effect of Repetitive Transcranial Stimulation (rTMS) as add-on treatment in mild-moderate dementia: a Randomised Controlled Trial Comparing Treatment as Usual vs Treatment as Usual with rTMS - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/03/106757

Enrollment

100

Registered

2026-03-23

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G30- Alzheimers disease

Interventions

Intervention1: rTMS with treatment as usual: rTMS protocol: Target: Left dorsolateral prefrontal cortex (DLPFC) Frequency: 10 Hz Intensity: 110% resting motor threshold Pulses: 2000 per session Sched

Eligibility

Inclusion criteria

Inclusion criteria: 1. Diagnosis of Alzheimer type of Dementia as per DSM-5 and NIA-AA criteria 2. Stable on medications Donepezil and or Memantine 10mg for at least 3 months 3. with Mini Mental State Examination score between 15 to 26

Exclusion criteria

Exclusion criteria: 1. Other neurological disorders affecting cognition 2. History of epilepsy or significant head injury 3. Implanted metallic devices or pacemakers 4. Other psychiatric illness including substance use disorder 5. Contraindications to MRI or rTMS

Design outcomes

Primary

Measure	Time frame
Change in cognition assessed by MoCA (Montreal Cognitive Assessment), Addenbrook Cognitive Examination (ACE) and Mini Mental State Examination (MMSE) scores from baselineTimepoint: 1 month, 3 months and 6 months	—

Secondary

Measure	Time frame
Assessment of functional status using the Bristol Activities of Daily Living (ADL)Timepoint: 1 month, 3 months, 6 months;Assessment of behavioural and psychological symptoms of dementia using the Neuropsychiatric Inventory (NPI)Timepoint: 1 month, 3 months, 6 months	—

Countries

India

Contacts

Public ContactTribeni Bhuyan

AIIMS Guwahati

tribenibhuyan@aiimsguwahati.ac.in9435697956

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026