None listed
Conditions
Interventions
Intervention1: GROUP I: Patients who will be receiving human amniotic membrane as scaffold for regeneration: After disinfection phase
Trim AM membrane to canal size.
Place in the canal 2 3 mm apical
centrifuge as per standardized protocol.
Prepare PRF membrane by gentle compression.
Place PRF at similar level (2 3 mm below CEJ).
Place MTA and coronal seal as above.
Sponsors
DR AMRITHA P K
Eligibility
Inclusion criteria
Inclusion criteria: Patients aged 13 25 years Immature permanent teeth Maxillary anterior teeth with open apices Necrotic pulp confirmed by history clinical signs and lack of response to sensibility tests Presence of periapical radiolucency suggestive of apical periodontitis less than 5mm radius Tooth must be structurally restorable Patients willing to return for scheduled follow ups Written informed consent from parent or guardian and assent from minors
Exclusion criteria
Exclusion criteria: Systemic diseases affecting healing such as uncontrolled diabetes immunocompromised states Known allergy to study materials like local anesthetic MTA components Teeth with root fractures or severe crown destruction Teeth with previous apexification or regenerative attempts Teeth with periapical radiolucency greater than 5mm radius Patients on medications affecting bleeding or healing Pregnant or lactating individuals Failure to obtain consent or assent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| No pain swelling sinus tract or mobilityTimepoint: Baseline 1 week 3 months 6 months 9 months 12 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Increase in root length (measured from CEJ to radiographic apex) Apical closure (open/closed) Periapical healing (PAI score) Timepoint: Baseline 1 week 3 months 6 months 9 months 12 months | — |
Countries
India
Contacts
Public ContactDR AMRITHA P K
Govt Dental College Kozhikode
Outcome results
None listed