Comparing two drugs to prevent waking up during brain surgery under full anesthesia

Comparative study of effect of Dexmedetomidine and Propofol on Intraoperative Awareness under general anaesthesia in Neurosurgical Patients. - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/03/106731

Enrollment

Registered

2026-03-23

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Dexmedetomidine: IV Dexmedetomidine (1 mcg/kg)followed by infusion at the rate of 0.5 mcg/kg/hr. Control Intervention1: Propofol: IV Propofol (1mg/kg for 10 min) followed by infusion at

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patient willing to give informed consent (ANNEXURE 1) 2. ASA grade I, II and III.(ANNEXURE 3) 3. Patients scheduled for elective neurosurgery under general anaesthesia 4. Patients aged between 18 and 60 years.

Exclusion criteria

Exclusion criteria: 1. Patient not willing to give informed consent 2. Patients known to have an allergy or hypersensitivity to dexmedetomidine and propofol. 3. Surgeries exceeding 3 hours 4. Patients with a heart rate of less than 50/min.

Design outcomes

Primary

Measure	Time frame
Intraoperative awareness in patients administered Dexmedetomidine will be better than Propofol.Timepoint: Assessment Wii be done at 12 hrs after surgery. Overall assessment will be done at 12 weeks	—

Secondary

Measure	Time frame
NilTimepoint: Nil	—

Countries

India

Contacts

Public ContactDr Jui A Jadhav

Datta Meghe Institute of Higher Education and Research

jui.jadhav@gmail.com8433660179

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026