Health Condition 1: - Health Condition 2: L818- Other specified disorders of pigmentation
Conditions
Interventions
Intervention1: TRANEXAMIC ACID 250 MG: Tranexamic acid DOSE - 250 MG Frequency - Once Daily Route - Oral along with advice of sunscreen application over involved area with Sun Protection Factor (SPF)
Sponsors
Eras Lucknow Medical College and Hospital Lucknow Uttar Pradesh India
Eligibility
Inclusion criteria
Inclusion criteria: All consenting patients aged 18 years above up to 60 years involving face and neck with a clinical diagnosis of lichen planus pigmentosus confirmed by dermoscopic evaluation, attending the dermatology outpatient department.
Exclusion criteria
Exclusion criteria: 1.Pregnant females, breastfeeding females, and women of reproductive age unwilling to use adequate contraception. 2.Patients with a known hypersensitivity to tranexamic acid or oral isotretinoin. 3.Patients who took treatment for LPP in past 3 months. 4.Patients with bleeding disorders (BT, CT, PT/INR will be done). 5.Patients with history of hepatic, renal or systemic disease. 6.Diagnosed Immunocompromised patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess and compare the efficacy of oral tranexamic acid and oral isotretinoin in reducing pigmentation and improving skin lesions in patients of lichen planus pigmentosus. Timepoint: 0.4,8,12,16 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.To analyse the efficacy of oral tranexamic acid in lichen planus pigmentosus. 2.To analyse the efficacy of oral isotretinoin in lichen planus pigmentosus. 3.To assess the side effects of oral tranexamic acid and oral isotretinoin. Timepoint: 0.4,8,12,16 weeks | — |
Countries
India
Contacts
Public ContactGurnoor Kaur
Department of Dermatology Venereology and Leprosy Eras Lucknow Medical College and Hospital
Outcome results
None listed