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To study the combined oxygenation and blood flow guided blood pressure management and its effect on neurological outcomes in severe head injury patients

Evaluation Of Combined Jugular Venous Oximetry (Sjvo2) And Transcranial Colour Coded Duplex (Tccd) Sonography Guided Haemodynamic Management And Its Effects On Neurological Outcomes In Severe Traumatic Brain Injury: A Randomised Controlled Trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/03/106713
Enrollment
108
Registered
2026-03-23
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: S062- Diffuse traumatic brain injury Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: TCCD combined with SjVO2 guided management: TCCD will be done every 4 hourly on the brain to get CPP and ICP values for 5 days after ICU

Sponsors

Dr Ankur Luthra
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with severe traumatic brain injury

Exclusion criteria

Exclusion criteria: Patients not giving consent, penetrating head trauma , Fixed, dilated pupils on admission, cardiac arrest before/during hospital stay, conditions with chronic anaemia, Contraindications to Jugular venous line placement (Coagulopathy, local infection, etc), Associated with High Cervical spine injury

Design outcomes

Primary

MeasureTime frame
To study the effects of combined SjvO2 monitoring plus TCCD guided haemodynamic management during the first 5 days of ICU admission after severe TBI vs conventional management on neurological outcomes at 3 months using the GOSE scaleTimepoint: 3 months after discharge from ICU—

Secondary

MeasureTime frame
To study the effects of combined monitoring vs conventional management on ICU length of stay, total hospital stay and neurological outcomes at discharge using the GOSE scale.Timepoint: At discharge from hospital;To study any complications associated with combined monitoring vs conventional monitoring during the first 5 days of ICU admission.Timepoint: 5 days—

Countries

India

Contacts

Public ContactAnkur Luthra

PGIMER, Chandigarh

zazzydude979@gmail.com01722756500

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026