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Evaluating the role of Pupil Size as a biomarker of Photophobia Severity in Migraine

Pupil Size as an objective Biomarker for Photophobia severity in migraine - MPSIZE

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/03/106655
Enrollment
120
Registered
2026-03-20
Start date
Unknown
Completion date
Unknown
Last updated
2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G439- Migraine, unspecified

Interventions

Intervention1: Nil: Nil

Sponsors

Ruby Moharana
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Participants meeting ICHD 3 criteria for migraine Participants 18 to 40 years old with migraine and photophobia Participants having light as a trigger factor for the migraine attack Participants with best corrected visual acuity 6/6 for distance and N6 for near Participants with normal anterior and posterior segments with normal IOP Participants with normal neurological assessment and normal MRI brain Participants voluntarily giving informed consent and agreed to answer the UPSIS12 Questionnaire

Exclusion criteria

Exclusion criteria: Participants with associated neurological disorder Participants with preexisting ocular conditions affecting pupil size Participants with recent eye surgeries Participants on any medications which can affect pupil size

Design outcomes

Primary

MeasureTime frame
Mean photopic pupil size measurement and its correlation to the UPSIS 12 scores Timepoint: Baseline

Secondary

MeasureTime frame
Mean photopic pupil size measurement & its correlation to the Migraine Disability Assessment scores MIDAS Timepoint: Baseline

Countries

India

Contacts

Public ContactRuby Moharana

DRIEMS Institute of Health Sciences and Hospital

rubymoharana@gmail.com07428968090

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Sep 19, 2026