A study comparing intravenous Ketamine and Lidocaine in reducing pain during Propofol injection.

To compare the efficacy of intravenous Ketamine versus preservative free Lidocaine in alleviating Propofol injection site pain A double blinded randomised control study - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/03/106645

Enrollment

120

Registered

2026-03-20

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: PCS-

Interventions

Intervention1: Pretreatment bolus with 1ml 2% preservative free Lidocaine IV: GROUP II will receive pretreatment bolus with 1ml of preservative free 2% Lidocaine. Sixty seconds after pretreatment bol

Eligibility

Inclusion criteria

Inclusion criteria: 1)Patients willing to give written informed consent for the study. 2)Patients with BMI 20-24kg/m2. 3)ASA physical status I and II. 4)Day care surgeries where Propofol is used for management. 5)Elective surgeries requiring general anaesthesia using Propofol as induction agent.

Exclusion criteria

Exclusion criteria: 1)Patients who have hypersensitivity to study drugs or its components. 2)Patients with acute or chronic pain syndromes. 3)Patients with history of upper respiratory tract infection/eosinophilia. 4)Patients taking sedatives or analgesics in the past 24 hours. 5)Pregnancy or lactating mothers. 6)History of seizures and / or dystonia. 7)Patients on any psychotropic drugs. 8)Patients with active Psychosis.

Design outcomes

Primary

Measure	Time frame
To grade the injection pain at the local site during Propofol injection for induction of general anaesthesia.Timepoint: 5 Seconds,10 Seconds,15 Seconds,20 Seconds,25 Seconds and 30 Seconds	—

Secondary

Measure	Time frame
1)Haemodynamic changes after injection of study drug 2)Effect on attenuation of intubation response after injection of study drug, if any. 3)Adverse events during the intraoperative period after the injection of study drug.Timepoint: Haemodynamic changes: 5 seconds, 10 seconds, 15 seconds and 30 seconds Post Intubation response: 0 minutes and 5 minutes	—

Countries

India

Contacts

Public ContactDr Yoganarasimha N

BGS Global Institute of Medical Sciences

yogaaims@gmail.com9845365348

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026