Comparison of three medicines used in tooth undergoing root canal treatment.

Comparative evaluation of antimicrobial efficacy of Calcium Hydroxide combined with saline, Calcium Hydroxide combined with 3% sodium hypochlorite and Sodium Dichloroisocyanurate alone as an intracanal medicament in multirooted necrosed teeth: A Randomized Double Blinded Clinical Study - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/03/106637

Enrollment

Registered

2026-03-20

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K041- Necrosis of pulp

Interventions

Intervention1: Sodium Dichloroisocyanurate alone as an intracanal medicament: Comparative evaluation of antimicrobial efficacy of Calcium Hydroxide combined with saline, Calcium Hydroxide combined wit

Eligibility

Inclusion criteria

Inclusion criteria: 1.Systemically healthy patients (Category: American Society of Anaesthesiologists class 1) (ASA House of Delegates 2014) aged between 18 60 years of age will be included. 2.Maxillary or mandibular completely matured multi-rooted tooth, diagnosed with pulp necrosis will be included 3.Maxillary or mandibular teeth having Periapical Index (PAI) Score 2 or more (according to PAI score classification) will be included. 4.Only those patients ready to sign the consent form will be included in the study.

Exclusion criteria

Exclusion criteria: 1.Vital teeth, teeth diagnosed with, cracks, internal/external root resorption or pulp canal obliteration and exhibiting clinical and/or radiographic signs of chronic/severe periodontitis will be excluded. 2.Teeth with previously endodontic treatment will be excluded. 3.Patients with severe periodontitis and poor oral hygiene will be excluded from the study. 4.Pregnant or lactating women will be excluded. 5.Patient not ready to give the consent will be excluded from the study.

Design outcomes

Primary

Measure	Time frame
To evaluate and compare antimicrobial efficacy of Calcium Hydroxide mixed with saline, Calcium Hydroxide mixed with 3% sodium hypochlorite and Sodium Dichloroisocyanurate as an intracanal medicament in multirooted necrosed teeth.Timepoint: At baseline and 7 days after the placement of intracanal medicament.	—

Secondary

Measure	Time frame
To measure & compare the MMP-9 levels using a specific enzyme-linked immunosorbent assay in each group.Timepoint: 7 days after the placement of intracanal medicament	—

Countries

India

Contacts

Public ContactDr Nimisha Shah

K M Shah Dental College and Hospital

nshah7873@gmail.com9998994299

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026