Health Condition 1: B968- Other specified bacterial agents as the cause of diseases classified elsewhere
Conditions
Interventions
Intervention1: Nil: Nil
Sponsors
All India Institute of Medical Sciences
All India Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 18 to 70 years Admitted to the ICU within 24 hours of having been diagnosed with septic shock defined by Sepsis 3 consensus guidelines as a Suspected or confirmed source of infection with Sequential organ failure assessment more than or equal to 2 and Shock defined as hypotension requiring persistent vasopressor therapy to maintain mean arterial pressure more than 65 mmHg and serum lactate levels greater than 2 mmol per litre despite adequate initial fluid resuscitation at least 30ml per kilogram of ideal body weight SAE diagnosed with cerebral dysfunction Glasgow Coma Scale less than or equal to 14 or with delirium caused by systemic responses to infections without structural abnormality, cerebral nervous system infection, and encephalopathy due to other causes such as hepatic, uremic, and toxic
Exclusion criteria
Exclusion criteria: Patients diagnosed with other causes of encephalopathy (hepatic, toxic, uremic, hypoxic) A pre-ICU diagnosis of cognitive dysfunction as indicated by their medical records on admission, or a primary central nervous system diagnosis like a cerebrovascular accident, meningitis, seizure disorder, psychiatric disorder, hypoxic encephalopathy post cardiac arrest. Life-threatening bleeding, the presence of hemorrhagic shock, as judged by research or treating clinicians Burns, Pregnancy Referral from or treated at other healthcare facilities Readmission to ICU Withdrawal of consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the cerebral oxyhemoglobin concentration in prefrontal cortex detected by fNIRS in patients with sepsis associated encephalopathy and patients without sepsis associated encephalopathyTimepoint: Day 1 and Day 3 | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare difference in following parameters in patients with and without sepsis associated encephalopathy Age Gender APACHE II score SOFA score Serum Sodium level Serum albumin levelTimepoint: Day 1 to Day 28 | — |
Countries
India
Contacts
Public ContactPuneet Khanna
All India Institute of Medical Sciences
Outcome results
None listed