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High pressure versus Low pressure non-invasive ventilation in Chronic Obstructive Pulmonary Disease worsening

High pressure noninvasive ventilation (NIV) versus Low pressure NIV in Acute hypercapnic respiratory failure patients with exacerbation of Chronic obstructive pulmonary disease (COPD) - HIPLO-COPD

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/03/106619
Enrollment
60
Registered
2026-03-20
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J40-J47- Chronic lower respiratory diseases

Interventions

Intervention1: High pressure Bipap: Ipap of 20-30 cm H2O till pH reverts to normal and hypercarbia resolves and the patient can be safely weaned off Bipap therapy. 3-6 days. Control Intervention1: Low

Sponsors

Christian Medical College Vellore
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Age more than 18, previously known or probable case of COPD, ABG showing acute type 2 Respiratory failure

Exclusion criteria

Exclusion criteria: Need for immediate intubation, contraindications to NIV, hemodynamic instability, poor sensorium, or facial trauma, overt clinical features of Heart failure, Age less than 18 years

Design outcomes

Primary

MeasureTime frame
Acidosis reversal within 24 hours with decrease in PCO2Timepoint: Acidosis reversal within 24 hours with decrease in PCO2—

Secondary

MeasureTime frame
Duration of hospital stay. Delaying the need for intubation, Patient tolerance to high pressure NIV, HACOR and ROX score improvementTimepoint: 0,1,6,12 and 24 hours and throughout the hospital stay—

Countries

India

Contacts

Public ContactNoel John Bijoy

Christian Medical College Vellore

drashwin_1985@cmcvellore.ac.in8427161885

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026