Role of Diet and Resistance Training in Preventing Relapse in Ulcerative Colitis with Sarcopenia

Effect of dietary intervention and resistance training on relapse rate among adult patients of Ulcerative colitis with sarcopenia : A randomized controlled trial - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/03/106585

Enrollment

Registered

2026-03-19

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K51- Ulcerative colitis

Interventions

Intervention1: High protein diet and resistance training: DietaryPlan: Individualized by a clinical dietitian based on total energy requirement (25 35 kcal/kg/day). High- quality protein sources (whey

Eligibility

Inclusion criteria

Inclusion criteria: Age 18 to 70 years Established diagnosis of Ulcerative colitis with standard criteria (Colonoscopy + histology, Ancillary investigations (ESR, CRP, Faecal calprotectin). Inactive ulcerative colitis Patients should be in remission at least 4 weeks prior to enrolment and on standard of care treatment Presence of sarcopenia at screening defined by South Asian working action group- Sarcopenia (SWAG- SARCO) criteria

Exclusion criteria

Exclusion criteria: 1.Active disease at enrollment 2. Clinical relapse or requirement for induction therapy or steroids within prior 4 weeks 3. Patients on biologicals 4. Chronic diseases that may affect muscle mass such as CLD, CHF, CKD, patients with rheumatic diseases 5. Intestinal obstruction 6. Toxic megacolon 7. Malignancy 8. Pregnancy 9. Neurological diseases like CVA, Parkinson s disease

Design outcomes

Primary

Measure	Time frame
To evaluate clinical relapse rates among adult patients of Ulcerative Colitis with sarcopenia randomized to high-protein diet plus structured resistance training programme versus standard of care.Timepoint: 3,6 and 12 months.	—

Secondary

Measure	Time frame
To evaluate change in muscle mass as determined by BIA, muscle strength as determined by handgrip & physical function as determined by gait speed between the two groups Timepoint: 3, 6 & 12 months;To assess the change in quality of life between the two groups using SF 36 questionnaire Timepoint: baseline & 12 months;To determine the need for biologicals/colectomy in both groupTimepoint: 3, 6 & 12 months.	—

Measure

Time frame

To evaluate change in muscle mass as determined by BIA, muscle strength as determined by handgrip & physical function as determined by gait speed between the two groups Timepoint: 3, 6 & 12 months;To assess the change in quality of life between the two groups using SF 36 questionnaire Timepoint: baseline & 12 months;To determine the need for biologicals/colectomy in both groupTimepoint: 3, 6 & 12 months.

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Countries

India

Contacts

Public ContactDr Anmol Saini

ABVIMS and Dr RML hospital

prajpoot15@gmail.com7570096707

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026