A Clinical study conducted on women suffering from Endometriosis related painful menstruation to evaluate how well Shoolahara Kashaya , Yavadi Utkarika and their combined use help in reducing pain during periods

A RANDOMISED OPEN LABELLED COMPARATIVE CLINICAL STUDY ON THE EFFICACY OF SHOOLAHARA KASHAYA AND YAVADI UTKARIKA AS A SINGLE THERAPIES AND IN COMBINATION ON PAIN MANAGEMENT IN ENDOMETRIOSIS RELATED TO SECONDARY DYSMENORRHEA - Nil

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/03/106572

Enrollment

Registered

2026-03-19

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N711- Chronic inflammatory disease of uterus

Interventions

Intervention1: Yavadi Utkarika: In Ashtang Sangraha Uttarasthana Adhyaya 39 Guhyaroga Pratishedha Shloka no 41-42. Yavadi Utkarika Drugs are mentioned They are Yava,, Godhuma ,Kinwa , Kushta , Shatpus

Eligibility

Inclusion criteria

Inclusion criteria: 1.Women of reproductive age group 20-50 years. 2.Participant clinically diagnosed with Endometriosis meeting one of the following criteria (confirmed by pelvic and rectal examination or ultrasound or laparoscopy). 3.Participant with any classical symptoms of secondary dysmenorrhea associated with Endometriosis. 4.History of Secondary dysmenorrhea with diagnosed Endometriosis 5.Regular menstrual cycles. 6.Participants with mild, moderate and severe pain based on NRS scoring. 7.Participant willing for trial will be selected and willing to participate in follow-up

Exclusion criteria

Exclusion criteria: 1.Participant diagnosed with Primary dysmenorrhea without any underlying pathology 2.Participant diagnosed with other pelvic pathologies like, uterine fibroids (Leiomyomas), PID, or malignancy of reproductive organs other than Endometriosis 3.Participant with chronic systemic diseases such as hypertension, uncontrolled diabetes, renal failure,Thyroid. 4.Participant with condition associated with the absence of regular menses Polycystic-ovarian syndrome, pregnant women and Lactating women. 5.Participant with an intrauterine device (IUD) or History of metallic implants,history of metallic injury. 6.Participants with less than 6 months of postpartum phase, post-abortion, or post-pregnancy at the time of entry into the trial. 7.Participant with unexplained irregular uterine bleeding. 8.Participant on recent hormonal therapy 9.Participant who is not willing for trial and not willing to participate in follow-up.

Design outcomes

Primary

Measure	Time frame
1.The efficacy of both Shoolahara Kashaya and Yavadi Utkarika will be established in the management of Secondary dysmenorrhea w.r.t. Pain management in Endometriosis . 2.The efficacy of Shoolahara Kashaya will be established in the management of Secondary dysmenorrhea w.r.t. Pain management in Endometriosis . 3.The efficacy of Yavadi Utkarika will be established in the management of Secondary dysmenorrhea w.r.t. Pain management in Endometriosis 4.Significant decrease in the symptoms of Secondary dysmenorrhea w.r.t. Pain management in Endometriosis will be assessed based on subjective and objective parameters related to disease. Timepoint: Group A Pre assessment 0th day (5-7 days before menstrual cycle) 1st assessment -After 1ST Menstrual cycle 2nd assessment - After 2nd Menstrual cycle Follow up (On trial without medicines Assessment) -After 3rd Menstrual cycle Group B Pre assessment 0th day (5-7 days before menstrual cycle) 1st assessment -After 1ST Menstrual cycle 2nd assessment - After 2nd Menstrual cycle Follow up (On trial without medicines Assessment) -After 3rd Menstrual cycle Group C Pre assessment 0th day (5-7 days before menstrual cycle) 1st assessment -After 1ST Menstrual cycle 2nd assessment - After 2nd Menstrual cycle Follow up (On trial without medicines Assessment) -After 3rd Menstrual cycle	—

Measure

Time frame

1.The efficacy of both Shoolahara Kashaya and Yavadi Utkarika will be established in the management of Secondary dysmenorrhea w.r.t. Pain management in Endometriosis . 2.The efficacy of Shoolahara Kashaya will be established in the management of Secondary dysmenorrhea w.r.t. Pain management in Endometriosis . 3.The efficacy of Yavadi Utkarika will be established in the management of Secondary dysmenorrhea w.r.t. Pain management in Endometriosis 4.Significant decrease in the symptoms of Secondary dysmenorrhea w.r.t. Pain management in Endometriosis will be assessed based on subjective and objective parameters related to disease. Timepoint: Group A Pre assessment 0th day (5-7 days before menstrual cycle) 1st assessment -After 1ST Menstrual cycle 2nd assessment - After 2nd Menstrual cycle Follow up (On trial without medicines Assessment) -After 3rd Menstrual cycle Group B Pre assessment 0th day (5-7 days before menstrual cycle) 1st assessment -After 1ST Menstrual cycle 2nd assessment - After 2nd Menstrual cycle Follow up (On trial without medicines Assessment) -After 3rd Menstrual cycle Group C Pre assessment 0th day (5-7 days before menstrual cycle) 1st assessment -After 1ST Menstrual cycle 2nd assessment - After 2nd Menstrual cycle Follow up (On trial without medicines Assessment) -After 3rd Menstrual cycle

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Secondary

Measure	Time frame
1.Improvement in menstrual cycle regularity 2.Reduction in symptoms of mood disturbance 3.Improvement in quality of life 4.Improvement in menstrual cycle characteristicsTimepoint: Group A Pre assessment 0th day (5-7 days before menstrual cycle) 1st assessment -After 1ST Menstrual cycle 2nd assessment - After 2nd Menstrual cycle Follow up (On trial without medicines Assessment) -After 3rd Menstrual cycle Group B Pre assessment 0th day (5-7 days before menstrual cycle) 1st assessment -After 1ST Menstrual cycle 2nd assessment - After 2nd Menstrual cycle Follow up (On trial without medicines Assessment) -After 3rd Menstrual cycle Group C Pre assessment 0th day (5-7 days before menstrual cycle) 1st assessment -After 1ST Menstrual cycle 2nd assessment - After 2nd Menstrual cycle Follow up (On trial without medicines Assessment) -After 3rd Menstrual cycle	—

Measure

Time frame

1.Improvement in menstrual cycle regularity 2.Reduction in symptoms of mood disturbance 3.Improvement in quality of life 4.Improvement in menstrual cycle characteristicsTimepoint: Group A Pre assessment 0th day (5-7 days before menstrual cycle) 1st assessment -After 1ST Menstrual cycle 2nd assessment - After 2nd Menstrual cycle Follow up (On trial without medicines Assessment) -After 3rd Menstrual cycle Group B Pre assessment 0th day (5-7 days before menstrual cycle) 1st assessment -After 1ST Menstrual cycle 2nd assessment - After 2nd Menstrual cycle Follow up (On trial without medicines Assessment) -After 3rd Menstrual cycle Group C Pre assessment 0th day (5-7 days before menstrual cycle) 1st assessment -After 1ST Menstrual cycle 2nd assessment - After 2nd Menstrual cycle Follow up (On trial without medicines Assessment) -After 3rd Menstrual cycle

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Countries

India

Contacts

Public ContactDr Shruti Patil

Sri Sri College Of Ayurvedic Science and Research Hospital , Bangalore

shrutivinsun@gmail.com9886269111

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026