Health Condition 1: I00-I99- Diseases of the circulatory system
Conditions
Interventions
Intervention1: MAP targets at differnt ranges.
55-60: Randomised to a MAP range, and the outcomes are compared against each other
Intervention2: MAP targets at differnt ranges. 60-65: Randomised to a
Sponsors
Sunnybrook Health Sciences Centre
Eligibility
Inclusion criteria
Inclusion criteria: 1 Ongoing vasopressor infusion to treat hypotension, or would be used to treat clinician defined hypotension as part of usual care; 2 MAP less than 75 mmHg at any point or lower than the upper value of the highest mean arterial pressure target range activated locally 3 Patient expected to be in the ICU for more than 48 hours.
Exclusion criteria
Exclusion criteria: 1. Treating team does not have equipoise for at least two consecutive MAP target ranges in the CEPEC Vasopressor Domain; 2. Acute traumatic brain injury (within 7 days or ongoing active treatment for elevated intracranial pressure); 3. Acute subarachnoid haemorrhage (within 21 days); 4. Acute spinal cord injury (within 7 days of injury or ongoing vasopressor therapy for suspected spinal cord ischemia); 5. Lung, heart, liver, kidney transplant recipient (within 7 days); 6. More than 24 hours since meeting the inclusion criteria in the ICU; 7. Previously randomised into the CEPEC Vasopressor Domain or a confounding trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 30-day composite endpoint incorporating mortality, persistent organ dysfunction (POD) in the ICU,13 ongoing hospital admissions, and discharge from the hospital with an increased level of care from baselineTimepoint: Day 30 | — |
Secondary
| Measure | Time frame |
|---|---|
| the individual components of the composite described above, and the number of days without POD in the ICUTimepoint: Day 30 | — |
Countries
Australia, Canada, Denmark, India, New Zealand, United Kingdom
Contacts
Public ContactVignesh M
Dr Kamakshi Memorial Hospitals
Outcome results
None listed