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Comparison of urinary biomarkers MMP 7 and TIMP 2 before and after surgery in children with pelviureteric junction obstruction.

A Prospective Study Comparing Urinary Biomarkers MMP-7 and TIMP-2 in Children with Pelvic Ureteric Junction Obstruction Before and After Pyeloplasty - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/03/106457
Enrollment
30
Registered
2026-03-18
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: Q620- Congenital hydronephrosis

Interventions

Intervention1: Nil: Nil

Sponsors

AIIMS Mangalagiri intramural grant
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: unilateral PUJO in children with 1m -18yrs

Exclusion criteria

Exclusion criteria: Bilateral PUJO, nephrotic syndrome, glomerulonephritis, diabetes mellitus, secondary PUJO due to stone disease, children with associated renal problems in addition to PUJO such as vesicoureteric reflux (VUR), posterior urethral valve (PUV), vesicoureteric junction obstruction (VUJO), and multi-cystic dysplastic kidney (MCDK)

Design outcomes

Primary

MeasureTime frame
1.Urinary MMP-7 and TIMP-2 levels will demonstrate significant changes following pyeloplasty, potentially correlating with functional improvementTimepoint: 1. 12 weeks 2. 24 weeks—

Secondary

MeasureTime frame
nilTimepoint:—

Countries

India

Contacts

Public ContactVutukuru lakshmi Sravanthi

AlIMS,Mangalagiri

vutukuru.sravanthi@gmail.com08885296197

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026