Health Condition 1: F102- Alcohol dependence
Conditions
Interventions
Intervention1: Baclofen: Baclofen is a GABA -B agonist, reduces CNS excitability commonly used to manage craving and withdrawal effects in alcohol dependence. It helps maintain abstinence and reduce d
Sponsors
Bhopal Memorial Hospital and Research Centre
Eligibility
Inclusion criteria
Inclusion criteria: 1. Male 2. Aged between 18-45 years 3. Is fulfilling the criteria of DSM-5 of Alcohol Use Disorder 4. Detoxified at the in-patient or out-patient Psychiatry department of BMHRC 5. Is assessed to be suffering from IAAC at the time of completion of detoxification 6. Can read Hindi or English 7. Is willing to give informed consent
Exclusion criteria
Exclusion criteria: EXCLUSION CRITERIA 1. Any other co-morbid substance use disorder other than Nicotine Use Disorder. 2. Any co-morbid psychiatric Disorder like Major Depression, Bipolar Mood Disorder, Schizophrenia etc. that can affect sleep. 3. Presence of any co-morbid medical conditions that contradicts the use of Gabapentin or Baclofen (Gabapentin and Baclofen primarily eliminated via kidneys). 4. On any Medication that is known to affect sleep e.g. sedating antidepressants, anticonvulsants, antipsychotic agents, centrally acting antihistamines or antihypertensives, oral corticosteroids, sedative-hypnotics, psychomotor stimulants, or theophylline as part of a General Medical Condition. 5. Known case of co-morbid Neurological condition, Obstructive Sleep Breathing Disorder or any sleep disorder. 6. Most Common adverse effects associated with Baclofen â?? oversedation, confusion, muscle weakness, vertigo, and nausea and with Gabapentin â?? dizziness, fatigue, ataxia, somnolence, nausea, etc. 7. History of hypersensitivity to Gabapentin or Baclofen
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessment of sleep parameters post detoxification in alcohol dependence.Timepoint: 0 week( Baseline) , 1 week, 4 week, and 8 week. | — |
Secondary
| Measure | Time frame |
|---|---|
| Assessment of craving post detoxification in alcohol dependence.Timepoint: 0 week( Baseline) , 1 week, 4 week, and 8 week. | — |
Countries
India
Contacts
Public ContactSanjukta Ghosh
BMHRC
Outcome results
None listed