Health Condition 1: L120- Bullous pemphigoid Health Condition 2: L121- Cicatricial pemphigoid Health Condition 3: L270- Generalized skin eruption due to drugs and medicaments taken internally Health Condition 4: L271- Localized skin eruption due to drugs and medicaments taken internally Health Condition 5: L20- Atopic dermatitis Health Condition 6: L23- Allergic contact dermatitis Health Condition 7: L10- Pemphigus Health Condition 8: L23- Allergic contact dermatitis Health Condition 9: L24- Irr
Conditions
Interventions
Intervention1: Nil: Nil
Sponsors
Father Muller Research Center
Eligibility
Inclusion criteria
Inclusion criteria: Cases: Age more than 18 years Clinically, histopathologically, and immunologically confirmed diagnosis of PV, BP,or MMP Presence of an intact, non-infected blister less than 48 hours old No prior treatment with systemic immunosuppressants in the preceding 2 weeks Control Age more than 18 years Diagnosis of non-autoimmune and non-infectious vesiculobullous dermatoses, such as Diabetic bullae (only if diabetes is controlled), Acute eczema with vesiculation (e.g., pompholyx, allergic contact dermatitis),Friction blisters, Second-degree thermal burns Presence of intact, non-infected blister less than 48 hours old
Exclusion criteria
Exclusion criteria: Cases Infected or ruptured blisters Recent systemic steroid or immunosuppressive therapy within the last 2 weeks Severe comorbidities such as uncontrolled diabetes mellitus, renal failure, or active systemic infection Controls Clinical or immunological suspicion of autoimmune blistering disease Infective blistering conditions e.g., bullous impetigo, cellulitis with blistering Ruptured blisters Immunocompromised states e.g., HIV, malignancy, chemotherapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the biochemical and cytological characteristics of blister fluid in patients with autoimmune blistering disordersTimepoint: At baseline (day of presentation), prior to initiation of systemic therapy, when blister fluid is aspirated from a fresh intact blister. | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation of biochemical and cytological parameters of blister fluid with specific autoimmune blistering disorders.Timepoint: At baseline;Association of blister fluid findings with clinical characteristics of the disease (site of lesions, morphology, duration).Timepoint: At baseline | — |
Countries
India
Contacts
Public ContactDr.Sonal Fernandes
Father Muller Medical College
Outcome results
None listed