A study comparing General Anaesthesia alone and General Anesthesia with Bilateral Erector Spinae Block with their effects on Stress Biomarkers After Spine Surgery.

A RANDOMIZED CLINICAL STUDY ON THE EFFECT OF TWO ANAESTHETIC TECHNIQUES ON VARIOUS LABORATORY BIOMARKERS AFTER SPINE SURGERY

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/03/106392

Enrollment

Registered

2026-03-17

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 8- Other Procedures

Interventions

Intervention1: General Anaesthesia + Errector Spinae Block: Errector Spinae Block will be given after General Anaesthesia and stress biomarkers are observed Post Operatively After 3 days Control Inter

Eligibility

Inclusion criteria

Inclusion criteria: Ammerican Society of Anaesthesiologists ASA physical status I III All patients admitted in CSSH scheduled to undergo spine surgeries.

Exclusion criteria

Exclusion criteria: 1.Type I or type II diabetes. 2.Oral contraceptives or Oestrogen therapy. 3.Body mass index more than 40 kg/m2. 4.Chronic analgesic therapy. 5.History of opioid dependence. 6.Those who receiving anticoagulation or experiencing any bleeding disorder. 7.Patients who required repeated surgical interventions. 8.Patient using chronic analgesic medication. 9.Psychiatric disorder. 10.Severe Hepatic , renal and neurological disease. 11.Emergency operation.

Design outcomes

Primary

Measure	Time frame
1.To compare the effect of two anaesthetic techniques (General Anaesthesia alone vs General Anaesthesia combined with Ultrasound-guided Erector Spinae Plane Block) on various laboratory biomarkers (testosterone,cortisol, CRP, glucose) in patients undergoing spine surgeries.Timepoint: 1.Glucose preoperative and postoperative after 6 hours 2.Testosterone, Cortisol, CRP preoperative and postoperative after 3 days	—

Measure

Time frame

1.To compare the effect of two anaesthetic techniques (General Anaesthesia alone vs General Anaesthesia combined with Ultrasound-guided Erector Spinae Plane Block) on various laboratory biomarkers (testosterone,cortisol, CRP, glucose) in patients undergoing spine surgeries.Timepoint: 1.Glucose preoperative and postoperative after 6 hours 2.Testosterone, Cortisol, CRP preoperative and postoperative after 3 days

—

Secondary

Measure	Time frame
1.To compare the haemodynamic parameters: Mean arterial pressure and Heart rate. 2.To assess the association between the anaesthetic technique in post operative pain score(VAS). Timepoint: 1.Heart rate and Mean Arterial Pressure will be monitored immediately postop and then at 15 min, 30 min, 45 min, 60 min, 2nd hour ,6th hour, 12th hour, and 24th hour post operatively. 2. Assessment of pain was done using VAS(Visual Analogue Scale) immediately and then at 15 min, 30 min, 45 min, 60 min, 2nd hour , 6th hour, 12th hour and 24th hour after surgery.	—

Measure

Time frame

1.To compare the haemodynamic parameters: Mean arterial pressure and Heart rate. 2.To assess the association between the anaesthetic technique in post operative pain score(VAS). Timepoint: 1.Heart rate and Mean Arterial Pressure will be monitored immediately postop and then at 15 min, 30 min, 45 min, 60 min, 2nd hour ,6th hour, 12th hour, and 24th hour post operatively. 2. Assessment of pain was done using VAS(Visual Analogue Scale) immediately and then at 15 min, 30 min, 45 min, 60 min, 2nd hour , 6th hour, 12th hour and 24th hour after surgery.

—

Countries

India

Contacts

Public ContactDR MANORANJAN KR BANSAL

Subharti Medical College

dr.manojbansal7@gmail.com7500693131

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026