A study to compare leech therapy and platelet rich plasma therapy in patients with chronic non healing wounds

Randomized Comparative Clinical Evaluation of Classical Regimen Irsal-i- Alaq (Hirudotherapy) versus Platelet-Rich Plasma Therapy in Qurooh-e-Muzmina (Chronic Ulcers) - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/03/106304

Enrollment

Registered

2026-03-16

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L979- Non-pressure chronic ulcer of unspecified part of lower leg

Interventions

Intervention1: Leech Therapy: Leech Therapy will be performed once weekly for a total of 8 sittings over 8 weeks Control Intervention1: Platelets Rich Plasma (PRP) therapy: Platelets Rich Plasma (PRP)

Eligibility

Inclusion criteria

Inclusion criteria: Diagnosed cases of chronic ulcers All adult patients from the age of 18yrs Both genders Patients having ulcers of grade II to V as per Wagner classification HbA1C is less than 7 (controlled diabetes)

Exclusion criteria

Exclusion criteria: Pregnant and lactating women Patients having psychological disorders Immunocompromised patients Patients on anticoagulant or antiplatelet therapy (aspirin warfarin clopidogrel etc) Patients of bleeding disorders and Severe anemia (Hb less than 8 g per dL) and hypotension Platelet dysfunction or platelet count less than 150000 per L (for PRP group) Known hypersensitivity to leech saliva or its components (for Leech group) Patients who refuse to sign the consent

Design outcomes

Primary

Measure	Time frame
To compare the Clinical outcome of Classical Regimen Irsal-i-Alaq (Hirudotherapy) with Platelets Rich Plasma (PRP) Therapy in Qurooh-e-Muzmina (Chronic Ulcers) Evaluate the effects of Platelet Rich Plasma (PRP) Therapy in the management of Qurooh-e-Muzmina (chronic ulcers) Evaluate the effects of Irsal-i-Alaq (Hirudotherapy) in the management of Qurooh-e-Muzmina (chronic ulcers) To Evaluate the post treatment change in Quality of Life of patients with Qurooh-e Muzmina (chronic ulcers)Timepoint: Baseline and at the end of treatment after 8 weeks	—

Measure

Time frame

To compare the Clinical outcome of Classical Regimen Irsal-i-Alaq (Hirudotherapy) with Platelets Rich Plasma (PRP) Therapy in Qurooh-e-Muzmina (Chronic Ulcers) Evaluate the effects of Platelet Rich Plasma (PRP) Therapy in the management of Qurooh-e-Muzmina (chronic ulcers) Evaluate the effects of Irsal-i-Alaq (Hirudotherapy) in the management of Qurooh-e-Muzmina (chronic ulcers) To Evaluate the post treatment change in Quality of Life of patients with Qurooh-e Muzmina (chronic ulcers)Timepoint: Baseline and at the end of treatment after 8 weeks

—

Secondary

Measure	Time frame
Biotechnological assessment of leech saliva for characterizationTimepoint: Baseline	—

Countries

India

Contacts

Public ContactMohammad Areeb

Department of Ilaj Bit Tadbeer Ajmal Khan Tibbiya College and Hospital

aasia.sultana@gmail.com8755199034

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026