Effect of Dexamethasone injection to prevent low blood pressure after spinal anaesthesia in elderly patients undergoing leg surgery.

To evaluate the efficacy of prophylactic intravenous dexamethasone in attenuating postspinal hypotension in geriatric patients undergoing lower limb orthopaedic surgery- A randomised controlled double blind study - nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/03/106278

Enrollment

Registered

2026-03-16

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Intravenous Dexamethasone in elderly patients undergoing lower limb orthopedic surgery under spinal anesthesia: Patients will receive 8 mg dexamethasone diluted in normal saline to a to

Eligibility

Inclusion criteria

Inclusion criteria: Patients belonging to the American Society of Anaesthesiologists-Physical Status I to III and aged 65 years or more of either sex, undergoing lower limb orthopaedic surgery under spinal anaesthesia will be included in the study.

Exclusion criteria

Exclusion criteria: The following patients will be excluded from the study:Patients refusing to give consent;Patients having spinal deformity, contraindications to spinal anesthesia (coagulopathy, thrombocytopenia, allergy to local anesthetics);Patients with known hypersensitivity to dexamethasone;Patients on chronic corticosteroid therapy, SSRI, antihypertensive drugs; BMImore than 30 kg per m2; Patients with cardiac diseases.

Design outcomes

Primary

Measure	Time frame
Incidence of post spinal hypotension after giving spinal anaesthesia. Hypotension will be defined as equal to or more than 20 percent decrease in mean arterial pressure from baseline following spinal anaesthesia.Timepoint: Heart Rate and Blood Pressure will be recorded before giving subarachnoid injection and then every 5 minutes for 30 minutes immediately after giving spinal anaesthesia and thereafter, every 15 minutes till the end of surgery or till 120 minutes, whichever is later.	—

Measure

Time frame

Incidence of post spinal hypotension after giving spinal anaesthesia. Hypotension will be defined as equal to or more than 20 percent decrease in mean arterial pressure from baseline following spinal anaesthesia.Timepoint: Heart Rate and Blood Pressure will be recorded before giving subarachnoid injection and then every 5 minutes for 30 minutes immediately after giving spinal anaesthesia and thereafter, every 15 minutes till the end of surgery or till 120 minutes, whichever is later.

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Secondary

Measure	Time frame
1. Vasopressor requirement Total dose of ephedrine required to treat hypotension.Timepoint: During intraoperative period.;2. Intravenous fluid requirement Total volume of intravenous fluid administered intraoperatively.Timepoint: During surgery;3. Incidence of bradycardia Bradycardia defined as heart rate less than 50 beats per minute requiring atropineTimepoint: During intraoperative period;4. Incidence of Nausea, vomiting and shivering following spinal anaesthesiaTimepoint: During intraoperative period;5. Total blood loss during surgery will be estimated and recorded.Timepoint: During intraoperative period	—

Measure

Time frame

1. Vasopressor requirement Total dose of ephedrine required to treat hypotension.Timepoint: During intraoperative period.;2. Intravenous fluid requirement Total volume of intravenous fluid administered intraoperatively.Timepoint: During surgery;3. Incidence of bradycardia Bradycardia defined as heart rate less than 50 beats per minute requiring atropineTimepoint: During intraoperative period;4. Incidence of Nausea, vomiting and shivering following spinal anaesthesiaTimepoint: During intraoperative period;5. Total blood loss during surgery will be estimated and recorded.Timepoint: During intraoperative period

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Countries

India

Contacts

Public ContactDr Kirtika Ojha

Pt.B.D. Sharma PGIMS Rohtak

aojha2013@gmail.com8745002563

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026